دورية أكاديمية
أعرض في EDS

Biomathematical modeling of fatigue due to sleep inertia.

التفاصيل البيبلوغرافية
العنوان: Biomathematical modeling of fatigue due to sleep inertia.
المؤلفون: McCauley ME; Sleep and Performance Research Center, Washington State University, 412 E. Spokane Falls Blvd., Spokane, WA 99202-2131, USA; Department of Translational Medicine and Physiology, Washington State University Health Sciences Spokane, 412 E. Spokane Falls Blvd., Spokane, WA 99202, USA. Electronic address: mark.mccauley@wsu.edu., McCauley P; Sleep and Performance Research Center, Washington State University, 412 E. Spokane Falls Blvd., Spokane, WA 99202-2131, USA., Kalachev LV; Department of Mathematical Sciences, University of Montana, Mathematics Building, Missoula, MT 59812, USA. Electronic address: kalachev@mso.umt.edu., Riedy SM; Sleep and Performance Research Center, Washington State University, 412 E. Spokane Falls Blvd., Spokane, WA 99202-2131, USA., Banks S; Behaviour-Brain-Body Research Centre, University of South Australia, Adelaide, SA 5048, Australia. Electronic address: siobhan.banks@unisa.edu.au., Ecker AJ; Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. Electronic address: ajecker@pennmedicine.upenn.edu., Dinges DF; Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. Electronic address: dinges@pennmedicine.upenn.edu., Van Dongen HPA; Sleep and Performance Research Center, Washington State University, 412 E. Spokane Falls Blvd., Spokane, WA 99202-2131, USA; Department of Translational Medicine and Physiology, Washington State University Health Sciences Spokane, 412 E. Spokane Falls Blvd., Spokane, WA 99202, USA. Electronic address: hvd@wsu.edu.
المصدر: Journal of theoretical biology [J Theor Biol] 2024 Aug 07; Vol. 590, pp. 111851. Date of Electronic Publication: 2024 May 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: London.
مواضيع طبية MeSH: Fatigue*/physiopathology , Sleep*/physiology , Models, Biological*, Humans ; Wakefulness/physiology ; Circadian Rhythm/physiology ; Sleep Deprivation/physiopathology
مستخلص: Biomathematical models of fatigue capture the physiology of sleep/wake regulation and circadian rhythmicity to predict changes in neurobehavioral functioning over time. We used a biomathematical model of fatigue linked to the adenosinergic neuromodulator/receptor system in the brain as a framework to predict sleep inertia, that is, the transient neurobehavioral impairment experienced immediately after awakening. Based on evidence of an adenosinergic basis for sleep inertia, we expanded the biomathematical model with novel differential equations to predict the propensity for sleep inertia during sleep and its manifestation after awakening. Using datasets from large laboratory studies of sleep loss and circadian misalignment, we calibrated the model by fitting just two new parameters and then validated the model's predictions against independent data. The expanded model was found to predict the magnitude and time course of sleep inertia with generally high accuracy. Analysis of the model's dynamics revealed a bifurcation in the predicted manifestation of sleep inertia in sustained sleep restriction paradigms, which reflects the observed escalation of the magnitude of sleep inertia in scenarios with sleep restriction to less than ∼ 4 h per day. Another emergent property of the model involves a rapid increase in the predicted propensity for sleep inertia in the early part of sleep followed by a gradual decline in the later part of the sleep period, which matches what would be expected based on the adenosinergic regulation of non-rapid eye movement (NREM) sleep and its known influence on sleep inertia. These dynamic behaviors provide confidence in the validity of our approach and underscore the predictive potential of the model. The expanded model provides a useful tool for predicting sleep inertia and managing impairment in 24/7 settings where people may need to perform critical tasks immediately after awakening, such as on-demand operations in safety and security, emergency response, and health care.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: R01 NR004281 United States NR NINR NIH HHS
فهرسة مساهمة: Keywords: Alertness; Awakening; Fatigue and performance models; Fatigue risk management; Temporal dynamics
تواريخ الأحداث: Date Created: 20240523 Date Completed: 20240613 Latest Revision: 20240618
رمز التحديث: 20240618
مُعرف محوري في PubMed: PMC11179995
DOI: 10.1016/j.jtbi.2024.111851
PMID: 38782198
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-8541
DOI:10.1016/j.jtbi.2024.111851