دورية أكاديمية
The mollifying effect of Sambucus nigra extract on StAR gene expression, oxidative stress, and apoptosis induced by fenpropathrin in male rats.
| العنوان: | The mollifying effect of Sambucus nigra extract on StAR gene expression, oxidative stress, and apoptosis induced by fenpropathrin in male rats. |
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| المؤلفون: | Nashed MS; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Hassanen EI; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Issa MY; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, Egypt., Tohamy AF; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Prince AM; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Hussien AM; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Soliman MM; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Electronic address: mahersoliman@cu.edu.eg. |
| المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Jul; Vol. 189, pp. 114744. Date of Electronic Publication: 2024 May 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Pyrethrins*/toxicity , Plant Extracts*/pharmacology , Oxidative Stress*/drug effects , Apoptosis*/drug effects , Sambucus nigra*/chemistry, Animals ; Male ; Rats ; Insecticides/toxicity ; Phosphoproteins/metabolism ; Phosphoproteins/genetics ; Testis/drug effects ; Testis/metabolism ; Spermatozoa/drug effects ; Spermatogenesis/drug effects ; Rats, Wistar ; Testosterone ; Caspase 3/metabolism ; Caspase 3/genetics ; Malondialdehyde/metabolism ; Antioxidants/pharmacology |
| مستخلص: | Fenpropathrin (FNP) is a man-made insecticide of to the pyrethroid class, commonly employed in agricultural and horticultural practices. However, it has a prolonged persistence in the environment. Sambucus nigra, also referred to as SN, is a botanical species recognized for its notable antioxidant characteristics. The objective of this study was to examine if SN extract could mitigate the reproductive toxicity induced by FNP in rats. A total of thirty rats were categorized into six distinct groups: a control group with no treatment, two groups getting SN extract at varying doses, a group receiving FNP, and two groups receiving both FNP and SN extract. The exposure to FNP led to a decline in the number and movement of sperm, lowered levels of testosterone, and reduced the activity of the StAR gene in the FNP group compared to the control group (p < 0.05). In addition, FNP resulted in a significant increase in malondialdehyde levels with a significant drop in GSH content compared to the control group (p < 0.05). Also, a significant increase in the expression of caspase 3. Nevertheless, the administration of SN extract alleviated these effects and reinstated spermatogenesis, thereby bringing the parameters closer to those observed in the control group. The data indicate that FNP can induce testicular harm and infertility, but SN extract can mitigate these detrimental consequences. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Caspase 3; Fenpropathrin; Oxidative stress; Sambucus nigra; StAR gene; Testes |
| المشرفين على المادة: | 0 (Pyrethrins) 0 (Plant Extracts) 87BH96P0MX (fenpropathrin) 0 (Insecticides) 0 (steroidogenic acute regulatory protein) 0 (Phosphoproteins) 3XMK78S47O (Testosterone) EC 3.4.22.- (Caspase 3) 4Y8F71G49Q (Malondialdehyde) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20240523 Date Completed: 20240613 Latest Revision: 20240613 |
| رمز التحديث: | 20240614 |
| DOI: | 10.1016/j.fct.2024.114744 |
| PMID: | 38782235 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6351 |
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| DOI: | 10.1016/j.fct.2024.114744 |