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Longitudinal associations of plasma kynurenines and ratios with fatigue and quality of life in colorectal cancer survivors up to 12 months post-treatment.

التفاصيل البيبلوغرافية
العنوان: Longitudinal associations of plasma kynurenines and ratios with fatigue and quality of life in colorectal cancer survivors up to 12 months post-treatment.
المؤلفون: Holthuijsen DDB; Department of Epidemiology, CARIM Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands.; Department of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., van Roekel EH; Department of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Bours MJL; Department of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Ueland PM; Bevital AS, Bergen, Norway., Breukink SO; Department of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.; NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands., Janssen-Heijnen MLG; Department of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands.; Department of Clinical Epidemiology, VieCuri Medical Centre, Venlo, The Netherlands., Keulen ETP; Department of Internal Medicine and Gastroenterology, Zuyderland Medical Centre Sittard-Geleen, Geleen, The Netherlands., Brezina S; Center for Cancer Research, Medical University of Vienna, Vienna, Austria., Gigic B; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Peoples AR; Huntsman Cancer Institute, Salt Lake City, Utah, USA., Ulrich CM; Huntsman Cancer Institute, Salt Lake City, Utah, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA., Ulvik A; Bevital AS, Bergen, Norway., Weijenberg MP; Department of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Eussen SJPM; Department of Epidemiology, CARIM Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands.; Department of Epidemiology, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
المصدر: International journal of cancer [Int J Cancer] 2024 Oct 01; Vol. 155 (7), pp. 1172-1190. Date of Electronic Publication: 2024 May 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 1995- : New York, NY : Wiley-Liss
Original Publication: 1966-1984 : Genève : International Union Against Cancer
مواضيع طبية MeSH: Kynurenine*/blood , Colorectal Neoplasms*/blood , Quality of Life* , Fatigue*/blood , Fatigue*/etiology , Cancer Survivors*/statistics & numerical data , Tryptophan*/blood, Humans ; Male ; Female ; Middle Aged ; Aged ; Longitudinal Studies ; Adult ; Kynurenic Acid/blood ; Tandem Mass Spectrometry ; Xanthurenates
مستخلص: Fatigue is prevalent in colorectal cancer (CRC) survivors, impacting their health-related quality of life (HRQoL). Inflammation-induced activation of the kynurenine pathway may play a role in cancer-related fatigue and HRQoL, but evidence is scarce. Therefore, we aimed to investigate longitudinal associations of plasma tryptophan, kynurenines, and ratios with fatigue and HRQoL in CRC survivors up to 12 months post-treatment. Repeated measurements at 6 weeks, 6 months, and 12 months post-treatment were performed in 249 stage I-III CRC survivors. Plasma tryptophan and eight kynurenines were analyzed using liquid chromatography-tandem mass spectrometry (LC/MS-MS). Fatigue and HRQoL outcomes were evaluated using validated questionnaires. Confounder-adjusted linear mixed models were conducted to analyze longitudinal associations, with false discovery rate (FDR) correction. Higher tryptophan (Trp), kynurenic acid (KA), and xanthurenic acid (XA) concentrations, as well as a higher kynurenic acid-to-quinolinic acid ratio (KA/QA), were associated with less fatigue and better functioning, while a higher kynurenine-to-tryptophan ratio (KTR) and 3-hydroxykynurenine ratio (HKr) were associated with more fatigue and worse functioning. Finally, higher KA and XA concentrations and a higher KA/QA ratio were associated with a higher overall HRQoL summary score, while a higher HKr was associated with a lower overall HRQoL summary score. In conclusion, we observed that tryptophan and several kynurenines were longitudinally associated with fatigue and HRQoL in CRC survivors up to 12 months post-treatment. Future research is needed to validate our findings and explore the potential of the kynurenine pathway as intervention target for reducing fatigue and enhancing HRQoL after CRC treatment.
(© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
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معلومات مُعتمدة: IIG_FULL_2020_018 Wereld Kanker Onderzoek Fonds; 2016/1620 Wereld Kanker Onderzoek Fonds; 2017/1619 Wereld Kanker Onderzoek Fonds; SG_2021_076 Wereld Kanker Onderzoek Fonds; 00005739 Health Foundation Limburg; 2021-1/13387 KWF Kankerbestrijding; UM 2010-4867 KWF Kankerbestrijding; UM 2012-5653 KWF Kankerbestrijding; UM 2014-6877 KWF Kankerbestrijding; 01KD2101D Bundesministerium für Bildung und Forschung; 01KT1503 Bundesministerium für Bildung und Forschung; R01 CA189184 United States CA NCI NIH HHS; U01 CA206110 United States CA NCI NIH HHS; R01 CA189184 United States CA NCI NIH HHS; U01 CA206110 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: colorectal cancer survivorship; fatigue; health‐related quality of life; plasma kynurenines; tryptophan
المشرفين على المادة: 343-65-7 (Kynurenine)
8DUH1N11BX (Tryptophan)
H030S2S85J (Kynurenic Acid)
58LAB1BG8J (xanthurenic acid)
0 (Xanthurenates)
تواريخ الأحداث: Date Created: 20240524 Date Completed: 20240802 Latest Revision: 20240802
رمز التحديث: 20240802
DOI: 10.1002/ijc.34992
PMID: 38783597
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0215
DOI:10.1002/ijc.34992