دورية أكاديمية
أعرض في EDS

3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice.

التفاصيل البيبلوغرافية
العنوان: 3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice.
المؤلفون: Searleman AC; Department of Radiology, University of California, San Diego, San Diego, CA, United States., Ma Y; Department of Radiology, University of California, San Diego, San Diego, CA, United States., Sampath S; Department of Radiology, University of California, San Diego, San Diego, CA, United States., Sampath S; Department of Radiology, University of California, San Diego, San Diego, CA, United States., Bussell R; Department of Radiology, University of California, San Diego, San Diego, CA, United States., Chang EY; Department of Radiology, University of California, San Diego, San Diego, CA, United States.; Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States., Deaton L; Novartis Institutes for BioMedical Research, San Diego, CA, United States., Schumacher AM; Novartis Institutes for BioMedical Research, San Diego, CA, United States., Du J; Department of Radiology, University of California, San Diego, San Diego, CA, United States.; Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States.; Department of Bioengineering, University of California, San Diego, San Diego, CA, United States.
المصدر: Frontiers in neuroimaging [Front Neuroimaging] 2024 May 09; Vol. 3, pp. 1356713. Date of Electronic Publication: 2024 May 09 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918402387106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2813-1193 (Electronic) Linking ISSN: 28131193 NLM ISO Abbreviation: Front Neuroimaging Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne] : Frontiers Media S.A., [2022]-
مستخلص: Purpose: To test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.
Methods: Non-aqueous myelin protons have ultrashort T 2 s and are "invisible" with conventional MRI sequences but can be detected with UTE sequences. The IR-UTE sequence uses an adiabatic inversion-recovery preparation to suppress the long T 2 water signal so that the remaining signal is from the ultrashort T 2 myelin component. In this study, eight 8-week-old C57BL/6 mice were fed cuprizone ( n = 4) or control chow ( n = 4) for 5 weeks and then imaged by 3D IR-UTE MRI. The differences in IR-UTE signal were compared in the major white matter tracts in the brain and correlated with the Luxol Fast Blue histochemical marker of myelin.
Results: IR-UTE signal decreased in cuprizone-treated mice in white matter known to be sensitive to demyelination in this model, such as the corpus callosum, but not in white matter known to be resistant to demyelination, such as the internal capsule. These findings correlated with histochemical staining of myelin content.
Conclusions: 3D IR-UTE MRI was sensitive to cuprizone-induced demyelination in the mouse brain, and is a promising noninvasive method for measuring brain myelin content.
Competing Interests: LD and AMS were employed by Novartis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(Copyright © 2024 Searleman, Ma, Sampath, Sampath, Bussell, Chang, Deaton, Schumacher and Du.)
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معلومات مُعتمدة: R01 AR079484 United States AR NIAMS NIH HHS; I01 CX002211 United States CX CSRD VA; R21 AR075851 United States AR NIAMS NIH HHS; T32 EB005970 United States EB NIBIB NIH HHS; I01 CX001388 United States CX CSRD VA; R01 AR075825 United States AR NIAMS NIH HHS; R01 NS092650 United States NS NINDS NIH HHS; RF1 AG075717 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: IR-UTE; MRI; cuprizone; mouse model; myelin imaging
تواريخ الأحداث: Date Created: 20240524 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11111995
DOI: 10.3389/fnimg.2024.1356713
PMID: 38783990
قاعدة البيانات: MEDLINE
الوصف
تدمد:2813-1193
DOI:10.3389/fnimg.2024.1356713