دورية أكاديمية
Viral Infection Leads to a Unique Suite of Allelopathic Chemical Signals in Three Diatom Host-Virus Pairs.
العنوان: | Viral Infection Leads to a Unique Suite of Allelopathic Chemical Signals in Three Diatom Host-Virus Pairs. |
---|---|
المؤلفون: | Edwards BR; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Falmouth, MA 02543, USA.; Department of Earth and Planetary Science, University of California-Berkeley, Berkeley, CA 94720, USA., Thamatrakoln K; Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901, USA., Fredricks HF; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Falmouth, MA 02543, USA., Bidle KD; Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901, USA., Van Mooy BAS; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Falmouth, MA 02543, USA. |
المصدر: | Marine drugs [Mar Drugs] 2024 May 17; Vol. 22 (5). Date of Electronic Publication: 2024 May 17. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2003]- |
مواضيع طبية MeSH: | Diatoms* , Oxylipins*/metabolism , Allelopathy*, Animals ; Aquatic Organisms ; Zooplankton |
مستخلص: | Ecophysiological stress and the grazing of diatoms are known to elicit the production of chemical defense compounds called oxylipins, which are toxic to a wide range of marine organisms. Here we show that (1) the viral infection and lysis of diatoms resulted in oxylipin production; (2) the suite of compounds produced depended on the diatom host and the infecting virus; and (3) the virus-mediated oxylipidome was distinct, in both magnitude and diversity, from oxylipins produced due to stress associated with the growth phase. We used high-resolution accurate-mass mass spectrometry to observe changes in the dissolved lipidome of diatom cells infected with viruses over 3 to 4 days, compared to diatom cells in exponential, stationary, and decline phases of growth. Three host virus pairs were used as model systems: Chaetoceros tenuissimus infected with CtenDNAV; C. tenuissimus infected with CtenRNAV; and Chaetoceros socialis infected with CsfrRNAV. Several of the compounds that were significantly overproduced during viral infection are known to decrease the reproductive success of copepods and interfere with microzooplankton grazing. Specifically, oxylipins associated with allelopathy towards zooplankton from the 6-, 9-, 11-, and 15-lipogenase (LOX) pathways were significantly more abundant during viral lysis. 9-hydroperoxy hexadecatetraenoic acid was identified as the strongest biomarker for the infection of Chaetoceros diatoms. C. tenuissimus produced longer, more oxidized oxylipins when lysed by CtenRNAV compared to CtenDNAV. However, CtenDNAV caused a more statistically significant response in the lipidome, producing more oxylipins from known diatom LOX pathways than CtenRNAV. A smaller set of compounds was significantly more abundant in stationary and declining C. tenuissimus and C. socialis controls. Two allelopathic oxylipins in the 15-LOX pathway and essential fatty acids, arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were more abundant in the stationary phase than during the lysis of C. socialis . The host-virus pair comparisons underscore the species-level differences in oxylipin production and the value of screening more host-virus systems. We propose that the viral infection of diatoms elicits chemical defense via oxylipins which deters grazing with downstream trophic and biogeochemical effects. |
References: | Anal Chem. 2006 Feb 1;78(3):779-87. (PMID: 16448051) iScience. 2023 Jul 18;26(8):107422. (PMID: 37575177) Metabolites. 2019 Apr 13;9(4):. (PMID: 31013937) Appl Environ Microbiol. 2008 Jul;74(13):4022-7. (PMID: 18469125) Nat Rev Microbiol. 2020 Jan;18(1):21-34. (PMID: 31690825) PLoS One. 2013 Dec 17;8(12):e82013. (PMID: 24358139) ISME J. 2021 Jan;15(1):41-54. (PMID: 32918065) ISME J. 2020 Jan;14(1):164-177. (PMID: 31611654) Angew Chem Int Ed Engl. 2000 Dec 1;39(23):4352-4354. (PMID: 29711885) Environ Microbiol. 2018 Aug;20(8):2880-2897. (PMID: 29921002) J Chem Ecol. 2020 Aug;46(8):771-781. (PMID: 32065342) Phytochemistry. 2007 Aug;68(15):2059-67. (PMID: 17575990) PLoS Biol. 2023 Jan 26;21(1):e3001966. (PMID: 36701270) Environ Microbiol. 2019 Aug;21(8):2948-2963. (PMID: 31106939) Prog Lipid Res. 2009 May-Jul;48(3-4):148-70. (PMID: 19268690) Appl Environ Microbiol. 1990 May;56(5):1400-5. (PMID: 16348190) Science. 2022 Jun 10;376(6598):1202-1208. (PMID: 35679415) Anal Chem. 2010 Dec 1;82(23):9818-26. (PMID: 21049934) Mar Drugs. 2012 Apr;10(4):775-792. (PMID: 22690143) J Appl Microbiol. 2021 Nov;131(5):2114-2130. (PMID: 33570824) Mar Genomics. 2015 Dec;24 Pt 1:89-94. (PMID: 25666254) Prog Lipid Res. 2018 Apr;70:1-16. (PMID: 29524459) Sci Data. 2024 Feb 13;11(1):193. (PMID: 38351090) ISME J. 2018 Feb;12(2):343-355. (PMID: 29028002) Metabolomics. 2007 Sep;3(3):211-221. (PMID: 24039616) Appl Environ Microbiol. 2009 Apr;75(8):2375-81. (PMID: 19233955) Curr Protoc Bioinformatics. 2012 Mar;Chapter 14:Unit14.11. (PMID: 22389014) Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19327-32. (PMID: 23134731) ISME J. 2022 Jun;16(6):1668-1675. (PMID: 35365738) Nat Microbiol. 2018 May;3(5):537-547. (PMID: 29531367) J Lipid Res. 2022 Dec;63(12):100302. (PMID: 36265716) Front Plant Sci. 2011 Oct 12;2:54. (PMID: 22629264) Mar Drugs. 2015 May 06;13(5):2834-56. (PMID: 25955757) Anal Bioanal Chem. 2020 Sep;412(23):5743-5757. (PMID: 32699965) Anal Chem. 2016 Jul 19;88(14):7154-62. (PMID: 27322848) Mol Plant Microbe Interact. 2013 Aug;26(8):977-86. (PMID: 23634839) Nat Commun. 2023 Jan 31;14(1):510. (PMID: 36720878) Mar Drugs. 2020 Jun 30;18(7):. (PMID: 32629777) Nat Microbiol. 2019 Nov;4(11):1790-1797. (PMID: 31308524) PLoS Comput Biol. 2017 Nov 3;13(11):e1005752. (PMID: 29099853) Anal Chem. 2012 Jan 3;84(1):283-9. (PMID: 22111785) Environ Microbiol. 2020 Feb;22(2):629-645. (PMID: 31782207) J Virol. 2013 May;87(10):5769-83. (PMID: 23487466) Int J Mol Sci. 2020 Jan 22;21(3):. (PMID: 31979078) Nat Biotechnol. 2020 Oct;38(10):1159-1163. (PMID: 32541957) Metabolomics. 2018 Jan 31;14(3):26. (PMID: 30830341) New Phytol. 2009;183(4):1064-1071. (PMID: 19538551) Science. 2015 May 22;348(6237):1261605. (PMID: 25999516) Proc Natl Acad Sci U S A. 2015 May 12;112(19):5909-14. (PMID: 25918397) Aquat Toxicol. 2008 Jan 31;86(2):249-55. (PMID: 18093670) BMC Bioinformatics. 2017 Feb 27;18(1):128. (PMID: 28241739) Cell Metab. 2014 Jan 7;19(1):21-36. (PMID: 24239568) ISME J. 2016 Feb;10(2):500-13. (PMID: 26262815) Org Biomol Chem. 2005 Nov 21;3(22):4065-70. (PMID: 16267584) Molecules. 2020 Jan 15;25(2):. (PMID: 31952163) Bioinformatics. 2010 Oct 1;26(19):2488-9. (PMID: 20671148) Anal Chem. 2021 Aug 31;93(34):11692-11700. (PMID: 34403256) Proc Natl Acad Sci U S A. 1997 May 13;94(10):5473-7. (PMID: 11038546) Aquat Toxicol. 2007 Dec 15;85(3):219-27. (PMID: 17942163) Protist. 2009 Aug;160(3):444-51. (PMID: 19386544) PLoS One. 2014 Jan 31;9(1):e85947. (PMID: 24497933) Curr Protoc Bioinformatics. 2019 Dec;68(1):e86. (PMID: 31756036) Ecotoxicology. 2010 Mar;19(3):493-511. (PMID: 19924531) Mar Drugs. 2014 Jan 17;12(1):368-84. (PMID: 24445306) Harmful Algae. 2016 May;55:221-229. (PMID: 28073535) J Chem Ecol. 2005 Apr;31(4):949-58. (PMID: 16124261) Mol Plant. 2012 Jul;5(4):914-28. (PMID: 22199234) |
معلومات مُعتمدة: | OIA-2021032 National Science Foundation; OCE-2049836 National Science Foundation; OCE-2231921 National Science Foundation; OCE- 2022597 National Science Foundation; OCE- 2020878 National Science Foundation |
فهرسة مساهمة: | Keywords: allelopathy; chemical signaling; diatom viruses; dissolved organic matter; lipid; lipidomics; marine virology; orbitrap mass spectrometry; oxylipins; viral ecology |
المشرفين على المادة: | 0 (Oxylipins) |
تواريخ الأحداث: | Date Created: 20240524 Date Completed: 20240524 Latest Revision: 20240526 |
رمز التحديث: | 20240526 |
مُعرف محوري في PubMed: | PMC11123003 |
DOI: | 10.3390/md22050228 |
PMID: | 38786618 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1660-3397 |
---|---|
DOI: | 10.3390/md22050228 |