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Viral Infection Leads to a Unique Suite of Allelopathic Chemical Signals in Three Diatom Host-Virus Pairs.

التفاصيل البيبلوغرافية
العنوان: Viral Infection Leads to a Unique Suite of Allelopathic Chemical Signals in Three Diatom Host-Virus Pairs.
المؤلفون: Edwards BR; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Falmouth, MA 02543, USA.; Department of Earth and Planetary Science, University of California-Berkeley, Berkeley, CA 94720, USA., Thamatrakoln K; Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901, USA., Fredricks HF; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Falmouth, MA 02543, USA., Bidle KD; Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901, USA., Van Mooy BAS; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Falmouth, MA 02543, USA.
المصدر: Marine drugs [Mar Drugs] 2024 May 17; Vol. 22 (5). Date of Electronic Publication: 2024 May 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Diatoms* , Oxylipins*/metabolism , Allelopathy*, Animals ; Aquatic Organisms ; Zooplankton
مستخلص: Ecophysiological stress and the grazing of diatoms are known to elicit the production of chemical defense compounds called oxylipins, which are toxic to a wide range of marine organisms. Here we show that (1) the viral infection and lysis of diatoms resulted in oxylipin production; (2) the suite of compounds produced depended on the diatom host and the infecting virus; and (3) the virus-mediated oxylipidome was distinct, in both magnitude and diversity, from oxylipins produced due to stress associated with the growth phase. We used high-resolution accurate-mass mass spectrometry to observe changes in the dissolved lipidome of diatom cells infected with viruses over 3 to 4 days, compared to diatom cells in exponential, stationary, and decline phases of growth. Three host virus pairs were used as model systems: Chaetoceros tenuissimus infected with CtenDNAV; C. tenuissimus infected with CtenRNAV; and Chaetoceros socialis infected with CsfrRNAV. Several of the compounds that were significantly overproduced during viral infection are known to decrease the reproductive success of copepods and interfere with microzooplankton grazing. Specifically, oxylipins associated with allelopathy towards zooplankton from the 6-, 9-, 11-, and 15-lipogenase (LOX) pathways were significantly more abundant during viral lysis. 9-hydroperoxy hexadecatetraenoic acid was identified as the strongest biomarker for the infection of Chaetoceros diatoms. C. tenuissimus produced longer, more oxidized oxylipins when lysed by CtenRNAV compared to CtenDNAV. However, CtenDNAV caused a more statistically significant response in the lipidome, producing more oxylipins from known diatom LOX pathways than CtenRNAV. A smaller set of compounds was significantly more abundant in stationary and declining C. tenuissimus and C. socialis controls. Two allelopathic oxylipins in the 15-LOX pathway and essential fatty acids, arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were more abundant in the stationary phase than during the lysis of C. socialis . The host-virus pair comparisons underscore the species-level differences in oxylipin production and the value of screening more host-virus systems. We propose that the viral infection of diatoms elicits chemical defense via oxylipins which deters grazing with downstream trophic and biogeochemical effects.
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معلومات مُعتمدة: OIA-2021032 National Science Foundation; OCE-2049836 National Science Foundation; OCE-2231921 National Science Foundation; OCE- 2022597 National Science Foundation; OCE- 2020878 National Science Foundation
فهرسة مساهمة: Keywords: allelopathy; chemical signaling; diatom viruses; dissolved organic matter; lipid; lipidomics; marine virology; orbitrap mass spectrometry; oxylipins; viral ecology
المشرفين على المادة: 0 (Oxylipins)
تواريخ الأحداث: Date Created: 20240524 Date Completed: 20240524 Latest Revision: 20240526
رمز التحديث: 20240526
مُعرف محوري في PubMed: PMC11123003
DOI: 10.3390/md22050228
PMID: 38786618
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md22050228