دورية أكاديمية
Comparison of dexmedetomidine versus propofol sedation on microcirculation and organ injuries in critically ill surgical patients: A randomized controlled pilot study.
| العنوان: | Comparison of dexmedetomidine versus propofol sedation on microcirculation and organ injuries in critically ill surgical patients: A randomized controlled pilot study. |
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| المؤلفون: | Chen PY; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan., Huang HH; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan., Chan WS; Department of Anesthesiology, Far Eastern Memorial Hospital, New Taipei, Taiwan., Liu CM; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan., Wu TT; Department of Anesthesiology, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu City, Taiwan., Chen JH; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan., Chao A; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan., Tien YW; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan., Chiu CT; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan., Yeh YC; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan. |
| المصدر: | Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2024 May 18. Date of Electronic Publication: 2024 May 18. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8622 (Electronic) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Ios Press Original Publication: Amsterdam ; Washington, DC : IOS Press, c1997- |
| مستخلص: | Background: Recent studies have shown that dexmedetomidine may improve microcirculation and prevent organ failure. However, most evidence was obtained from experimental animals and patients receiving cardiac surgery with cardiopulmonary bypass. This study aimed to investigate the effect of dexmedetomidine on microcirculation and organ injuries in critically ill general surgical patients. Methods: In this prospective randomized trial, patients admitted to the surgical intensive care unit after general surgery were enrolled and randomly allocated to the dexmedetomidine or propofol groups. Patients received continuous dexmedetomidine or propofol infusions to meet their requirement of sedation according to their grouping. At each time point, sublingual microcirculation images were obtained using the incident dark field video microscope. Results: Overall, 60 patients finished the trial and were analyzed. Microcirculation parameters did not differ significantly between two groups. Heart rate at 4 h after ICU admission and mean arterial pressures at 12 h and 24 h after ICU admission were lower in the dexmedetomidine group than in the propofol group. At 24 h, serum aspartate aminotransferase (41 (25-118) vs 86 (34-129) U/L, p = 0.035) and alanine aminotransferase (50 (26-160) vs 68 (35-172) U/L, p = 0.019) levels were significantly lower in the dexmedetomidine group than in the propofol group. Conclusion: Microcirculation parameters did not differ significantly between the dexmedetomidine and propofol groups. At 24 h after ICU admission, serum liver enzyme levels were lower in patients receiving dexmedetomidine as compared to propofol. |
| فهرسة مساهمة: | Keywords: Microcirculation; critical care; dexmedetomidine; propofol; surgery |
| تواريخ الأحداث: | Date Created: 20240524 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| DOI: | 10.3233/CH-232093 |
| PMID: | 38788060 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-8622 |
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| DOI: | 10.3233/CH-232093 |