دورية أكاديمية
Moderate chronic sleep perturbation impairs glucose and lipid homeostasis in rats.
| العنوان: | Moderate chronic sleep perturbation impairs glucose and lipid homeostasis in rats. |
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| المؤلفون: | Tonet NS; Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.; Graduate Program in Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., da Silva Marçal DF; Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., da Silva FN; Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Brunetta HS; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, Brazil., Mori MADS; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, Brazil., Dos Santos GJ; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Moreira ELG; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Rafacho A; Laboratory of Investigation in Chronic Diseases (LIDoC), Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.; Graduate Program in Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil. |
| المصدر: | Sleep [Sleep] 2024 Jul 11; Vol. 47 (7). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Print Cited Medium: Internet ISSN: 1550-9109 (Electronic) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: New York, Raven Press. |
| مواضيع طبية MeSH: | Sleep Deprivation*/physiopathology , Sleep Deprivation*/complications , Sleep Deprivation*/metabolism , Rats, Wistar* , Homeostasis*/physiology , Insulin Resistance*/physiology , Blood Glucose*/metabolism, Animals ; Male ; Female ; Rats ; Lipid Metabolism ; Insulin/metabolism ; Insulin/blood ; Glucose Intolerance/physiopathology ; Adiposity/physiology ; Eating/physiology ; Leptin/blood |
| مستخلص: | Study Objectives: Sleep deprivation is a potential risk factor for metabolic diseases, including obesity and type 2 diabetes. We evaluated the impacts of moderate chronic sleep deprivation on glucose and lipid homeostasis in adult rats. Methods: Wistar rats (both sexes) were sleep-perturbed daily for 2 hours at the early (06:00-08:00) and the late light cycle (16:00-18:00) five days a week (except weekends) for 4 weeks. Results: Sleep perturbation (SP) resulted in reduced body weight gain in both sexes, associated with altered food intake and reduced adiposity. SP did not alter the short- or long-term memories or cause anxiogenic behavior. No major changes were observed in the plasma insulin, leptin, triacylglycerol, non-esterified fatty acids, and blood glucose upon SP. After SP, females exhibited a transitory glucose intolerance, while males became glucose intolerant at the end of the experimental period. Male rats also developed higher insulin sensitivity at the end of the SP protocol. Morphometric analyses revealed no changes in hepatic glycogen deposition, pancreatic islet mass, islet-cell distribution, or adrenal cortex thickness in SP rats from both sexes, except for lower adipocyte size compared with controls. We did not find homogeneous changes in the relative expression of circadian and metabolic genes in muscle or hepatic tissues from the SP rats. Conclusions: Moderate chronic SP reduces visceral adiposity and causes glucose intolerance with a more pronounced impact on male rats, reinforcing the metabolic risks of exposure to sleep disturbances. (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| معلومات مُعتمدة: | 2019/21852-1, 2022/00358-1, 2021/08354-2 Fundação de Amparo à Pesquisa do Estado de São Paulo; CP48/2021 Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina |
| فهرسة مساهمة: | Keywords: circadian cycle; clock genes; diabetes; obesity; sleep deprivation |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Insulin) 0 (Leptin) |
| تواريخ الأحداث: | Date Created: 20240524 Date Completed: 20240711 Latest Revision: 20240711 |
| رمز التحديث: | 20240711 |
| DOI: | 10.1093/sleep/zsae118 |
| PMID: | 38788154 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-9109 |
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| DOI: | 10.1093/sleep/zsae118 |