دورية أكاديمية
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration.
| العنوان: | Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration. |
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| المؤلفون: | Vessey KA; Department of Anatomy and Physiology, The University of Melbourne, VIC 3010, Australia; School of Science and Technology, The University of New England, NSW 2350, Australia., Jobling AI; Department of Anatomy and Physiology, The University of Melbourne, VIC 3010, Australia., Greferath U; Department of Anatomy and Physiology, The University of Melbourne, VIC 3010, Australia., Fletcher EL; Department of Anatomy and Physiology, The University of Melbourne, VIC 3010, Australia. Electronic address: e.fletcher@unimelb.edu.au. |
| المصدر: | Current opinion in pharmacology [Curr Opin Pharmacol] 2024 Jun; Vol. 76, pp. 102463. Date of Electronic Publication: 2024 May 23. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4973 (Electronic) Linking ISSN: 14714892 NLM ISO Abbreviation: Curr Opin Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Elsevier Science Ltd., 2001- |
| مواضيع طبية MeSH: | Autophagy*/drug effects , Macular Degeneration*/drug therapy, Humans ; Animals |
| مستخلص: | Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the elderly. Although new therapies have recently emerged, there are currently no ways of preventing the development of the disease. Changes in intracellular recycling processes. Changes in intracellular recycling processes, called autophagy, lead to debris accumulation and cellular dysfunction in AMD models and AMD patients. Drugs that enhance autophagy hold promise as therapies for slowing AMD progression in preclinical models; however, more studies in humans are required. While a definitive cure for AMD will likely hinge on a personalized medicine approach, treatments that enhance autophagy hold promise for slowing vision loss. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20240524 Date Completed: 20240613 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.1016/j.coph.2024.102463 |
| PMID: | 38788268 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1471-4973 |
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| DOI: | 10.1016/j.coph.2024.102463 |