دورية أكاديمية
أعرض في EDS

Long-Term Structural Changes in the Osteochondral Unit in Patients with Osteoarthritis Undergoing Corrective Osteotomy with Platelet-Rich Plasma or Stromal Vascular Fraction Post-Treatment.

التفاصيل البيبلوغرافية
العنوان: Long-Term Structural Changes in the Osteochondral Unit in Patients with Osteoarthritis Undergoing Corrective Osteotomy with Platelet-Rich Plasma or Stromal Vascular Fraction Post-Treatment.
المؤلفون: Prizov A; Department of Traumatology and Orthopaedics, RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia., Tchetina E; Immunology and Molecular Biology Laboratory, Nasonova Research Institute of Rheumatology, Kashirskoe Shosse 34A, Moscow 115522, Russia., Volkov A; Department of Pathological Anatomy, RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia.; Laboratory of Bone Tissue Pathology, Research Institute of Human Morphology, n.a. akad A.P. Avtsyna, Petrovsky National Research Center of Surgery, Abrikosovsky lane 2, Moscow 119435, Russia., Eremin I; Surgery Department, Petrovsky National Research Center of Surgery, Abrikosovsky lane 2, Moscow 119435, Russia., Zagorodniy N; Department of Traumatology and Orthopaedics, RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia.; National Medical Research Center of Traumatology and Orthopedics, n.a. N.N. Priorov, Priorova Str. 10, Moscow 127299, Russia., Lazko F; Department of Traumatology and Orthopaedics, RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia., Pulin A; Pirogov National Medical and Surgical Center, Nizhnyaya Pervomayskaya Str. 70, Moscow 105203, Russia., Belyak E; Department of Traumatology and Orthopaedics, RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia., Kotenko K; Surgery Department, Petrovsky National Research Center of Surgery, Abrikosovsky lane 2, Moscow 119435, Russia., Eshmotova G; Department of Pathological Anatomy, RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia., Glukhova S; Immunology and Molecular Biology Laboratory, Nasonova Research Institute of Rheumatology, Kashirskoe Shosse 34A, Moscow 115522, Russia., Lila A; Immunology and Molecular Biology Laboratory, Nasonova Research Institute of Rheumatology, Kashirskoe Shosse 34A, Moscow 115522, Russia.
المصدر: Biomedicines [Biomedicines] 2024 May 09; Vol. 12 (5). Date of Electronic Publication: 2024 May 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: This pilot study examined the long-term structural changes in the osteochondral unit of 20 patients with knee osteoarthritis (KOA) who underwent high tibial osteotomy (HTO) and received post-treatment with either platelet-rich plasma (PRP) or stromal vascular fraction (SVF). Ten patients were injected with autologous PRP (PRP subgroup), while another ten patients received autologous SVF (SVF subgroup) six weeks after surgery and were monitored for 18 months. Histological samples of bone and cartilage (2 mm in diameter and 2 cm long) were taken from tibial and femoral sites during surgery and 18-month post-HTO, and morphometric analyses were conducted using Mega-Morf12 software. Both post-treatment resulted in an increase in articular cartilage height at both sites ( p < 0.001 in the tibia and femur), indicating positive outcomes. Significant improvements in subchondral and trabecular bone architecture were also observed, with SVF injection showing higher reparative capacity in terms of bone volume ( p < 0.001 for the tibia and p = 0.004 for the femur), subchondral bone height ( p < 0.001 for the tibia and p = 0.014 for the femur), trabecular bone volume ( p < 0.001 for the femur), and intertrabecular space ( p = 0.009 for the tibia and p = 0.007 for the femur). This pilot study, for the first time, demonstrates that HTO surgery combined with PRP and SVF post-treatments can lead to significant enhancements in knee articular cartilage and bone architecture in KOA patients, with SVF showing higher regenerative potential. These findings may contribute to improving treatment strategies for better clinical outcomes in HTO therapy for patients with KOA.
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معلومات مُعتمدة: 1021062512064-0 Russian Ministry of Education and Science
فهرسة مساهمة: Keywords: corrective osteotomy; knee osteoarthritis; morphometry; osteochondral unit; platelet-rich plasma; stromal vascular fraction
تواريخ الأحداث: Date Created: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11118028
DOI: 10.3390/biomedicines12051044
PMID: 38791006
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines12051044