دورية أكاديمية
Systems for Targeted Silencing of Gene Expression and Their Application in Plants and Animals.
العنوان: | Systems for Targeted Silencing of Gene Expression and Their Application in Plants and Animals. |
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المؤلفون: | Motorina DM; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Galimova YA; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Battulina NV; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Omelina ES; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2024 May 11; Vol. 25 (10). Date of Electronic Publication: 2024 May 11. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Plants*/genetics , Plants*/metabolism , Gene Silencing* , CRISPR-Cas Systems*, Animals ; RNA Interference ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Optogenetics/methods ; Gene Expression Regulation ; Zinc Fingers/genetics |
مستخلص: | At present, there are a variety of different approaches to the targeted regulation of gene expression. However, most approaches are devoted to the activation of gene transcription, and the methods for gene silencing are much fewer in number. In this review, we describe the main systems used for the targeted suppression of gene expression (including RNA interference (RNAi), chimeric transcription factors, chimeric zinc finger proteins, transcription activator-like effectors (TALEs)-based repressors, optogenetic tools, and CRISPR/Cas-based repressors) and their application in eukaryotes-plants and animals. We consider the advantages and disadvantages of each approach, compare their effectiveness, and discuss the peculiarities of their usage in plant and animal organisms. This review will be useful for researchers in the field of gene transcription suppression and will allow them to choose the optimal method for suppressing the expression of the gene of interest depending on the research object. |
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معلومات مُعتمدة: | 22-74-10118 Russian science foundation |
فهرسة مساهمة: | Keywords: CRISPR/Cas; RNAi; TALE; gene silencing; optogenetics; zinc finger protein |
المشرفين على المادة: | 0 (Transcription Factors) |
تواريخ الأحداث: | Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240528 |
رمز التحديث: | 20240528 |
مُعرف محوري في PubMed: | PMC11121118 |
DOI: | 10.3390/ijms25105231 |
PMID: | 38791270 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms25105231 |