دورية أكاديمية
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Whey Protein Isolate as a Substrate to Design Calendula officinalis Flower Extract Controlled-Release Materials.

التفاصيل البيبلوغرافية
العنوان: Whey Protein Isolate as a Substrate to Design Calendula officinalis Flower Extract Controlled-Release Materials.
المؤلفون: Stachowiak-Trojanowska N; Faculty of Chemistry, Nicolaus Copernicus University in Torun, ul. Gagarina 7, 87-100 Torun, Poland., Walendziak W; Faculty of Chemistry, Nicolaus Copernicus University in Torun, ul. Gagarina 7, 87-100 Torun, Poland., Douglas TEL; School of Engineering, Lancaster University, Lancaster LA1 4YW, UK., Kozlowska J; Faculty of Chemistry, Nicolaus Copernicus University in Torun, ul. Gagarina 7, 87-100 Torun, Poland.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 13; Vol. 25 (10). Date of Electronic Publication: 2024 May 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Calendula*/chemistry , Flowers*/chemistry , Plant Extracts*/chemistry , Whey Proteins*/chemistry , Tensile Strength* , Delayed-Action Preparations*/chemistry, Alginates/chemistry ; Gelatin/chemistry ; Microspheres
مستخلص: The use of natural active substances and the development of new formulations are promising directions in the cosmetic and pharmacy industries. The primary purpose of this research was the production of microparticles based on whey protein isolate (WPI) and calcium alginate (ALG) containing Calendula officinalis flower extract and their incorporation into films composed of gelatin, WPI, and glycerol. Both swollen and dry microparticles were studied by optical microscopy and their sizes were measured. Water absorption by the microparticles, their loading capacity, and the release profile of flower extract were also characterized. The films were analyzed by mechanical tests (Young's modulus, tensile strength, elongation at break), swelling capacity, contact angle, and moisture content measurements. The presented data showed that the active ingredient was successfully enclosed in spherical microparticles and completely released after 75 min of incubation at 37 °C. The incorporation of the microparticles into polymer films caused a decrease in stiffness and tensile strength, simultaneously increasing the ductility of the samples. Moreover, the films containing microparticles displayed higher swelling ability and moisture content compared to those without them. Hence, the materials prepared in this study with Calendula officinalis flower extract encapsulated into polymeric microspheres can be a starting point for the development of new products intended for skin application; advantages include protection of the extract against external factors and a controlled release profile.
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معلومات مُعتمدة: UMO2016/21/D/ST8/01705 National Science Center
فهرسة مساهمة: Keywords: Calendula officinalis flower extract; gelatin; microparticles; polymeric films; sodium alginate; whey protein isolate
المشرفين على المادة: 0 (Plant Extracts)
0 (Whey Proteins)
0 (Delayed-Action Preparations)
0 (Alginates)
9000-70-8 (Gelatin)
تواريخ الأحداث: Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11120854
DOI: 10.3390/ijms25105325
PMID: 38791364
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25105325