دورية أكاديمية
أعرض في EDS

Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes.

التفاصيل البيبلوغرافية
العنوان: Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes.
المؤلفون: Nguyen N; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA., Woodside DB; Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada., Lam E; Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada., Quehenberger O; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA., German JB; Department of Food Science & Technology, University of California, Davis, Davis, CA 95616, USA., Shih PB; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 18; Vol. 25 (10). Date of Electronic Publication: 2024 May 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Anorexia Nervosa*/metabolism , Fatty Acids*/metabolism, Humans ; Female ; Adult ; Young Adult ; Lipogenesis ; Eicosapentaenoic Acid/metabolism ; Lauric Acids/metabolism ; Fatty Acid Elongases/metabolism ; Adolescent ; Fatty Acid Desaturases/metabolism ; Case-Control Studies ; Fatty Acids, Unsaturated
مستخلص: Disordered eating behavior differs between the restricting subtype (AN-R) and the binging and purging subtype (AN-BP) of anorexia nervosa (AN). Yet, little is known about how these differences impact fatty acid (FA) dysregulation in AN. To address this question, we analyzed 26 FAs and 7 FA lipogenic enzymes (4 desaturases and 3 elongases) in 96 women: 25 AN-R, 25 AN-BP, and 46 healthy control women. Our goal was to assess subtype-specific patterns. Lauric acid was significantly higher in AN-BP than in AN-R at the fasting timepoint ( p = 0.038) and displayed significantly different postprandial changes 2 h after eating. AN-R displayed significantly higher levels of n-3 alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid (EPA), docosapentaenoic acid, and n-6 linoleic acid and gamma-linolenic acid compared to controls. AN-BP showed elevated EPA and saturated lauric acid compared to controls. Higher EPA was associated with elevated anxiety in AN-R ( p = 0.035) but was linked to lower anxiety in AN-BP ( p = 0.043). These findings suggest distinct disordered eating behaviors in AN subtypes contribute to lipid dysregulation and eating disorder comorbidities. A personalized dietary intervention may improve lipid dysregulation and enhance treatment effectiveness for AN.
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معلومات مُعتمدة: R01MH106781 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: anorexia nervosa; desaturases; elongases; fatty acids
المشرفين على المادة: 0 (Fatty Acids)
AAN7QOV9EA (Eicosapentaenoic Acid)
0 (Lauric Acids)
1160N9NU9U (lauric acid)
EC 2.3.1.- (Fatty Acid Elongases)
EC 1.14.19.- (Fatty Acid Desaturases)
NS3OZT14QT (docosapentaenoic acid)
0 (Fatty Acids, Unsaturated)
تواريخ الأحداث: Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11122126
DOI: 10.3390/ijms25105516
PMID: 38791555
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25105516