دورية أكاديمية
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Anticancer Activity and Molecular Mechanisms of Acetylated and Methylated Quercetin in Human Breast Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Anticancer Activity and Molecular Mechanisms of Acetylated and Methylated Quercetin in Human Breast Cancer Cells.
المؤلفون: Sakao K; The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima 890-0065, Japan.; Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University, Kagoshima 890-0065, Japan., Hamamoto S; Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University, Kagoshima 890-0065, Japan., Urakawa D; The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima 890-0065, Japan., He Z; The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima 890-0065, Japan., Hou DX; The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima 890-0065, Japan.; Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University, Kagoshima 890-0065, Japan.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 May 20; Vol. 29 (10). Date of Electronic Publication: 2024 May 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Quercetin*/pharmacology , Quercetin*/analogs & derivatives , Quercetin*/chemistry , Breast Neoplasms*/metabolism , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Apoptosis*/drug effects , Cell Proliferation*/drug effects, Humans ; Acetylation/drug effects ; Methylation ; Female ; MCF-7 Cells ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Tumor Suppressor Protein p53/metabolism ; Caspase 3/metabolism
مستخلص: Quercetin, a flavonoid polyphenol found in many plants, has garnered significant attention due to its potential cancer chemoprevention. Our previous studies have shown that acetyl modification of the hydroxyl group of quercetin altered its antitumor effects in HepG2 cells. However, the antitumor effect in other cancer cells with different gene mutants remains unknown. In this study, we investigated the antitumor effect of quercetin and its methylated derivative 3,3',4',7- O -tetramethylquercetin (4Me-Q) and acetylated derivative 3,3',4',7- O -tetraacetylquercetin (4Ac-Q) on two human breast cancer cells, MCF-7 (wt-p53, caspase-3-ve) and MDA-MB-231 (mt-p53, caspase-3+ve). The results demonstrated that 4Ac-Q exhibited significant cell proliferation inhibition and apoptosis induction in both MCF-7 and MDA-MB-231 cells. Conversely, methylation of quercetin was found to lose the activity. The human apoptosis antibody array revealed that 4Ac-Q might induce apoptosis in MCF-7 cells via a p53-dependent pathway, while in MDA-MB-231 cells, it was induced via a caspase-3-dependent pathway. Furthermore, an evaluation using a superoxide inhibitor, MnTBAP, revealed 4Ac-Q-induced apoptosis in MCF-7 cells in a superoxide-independent manner. These findings provide valuable insights into the potential of acetylated quercetin as a new approach in cancer chemoprevention and offer new avenues for health product development.
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معلومات مُعتمدة: JP19K05931, JP16K1870 Japan Society for the Promotion of Science
فهرسة مساهمة: Keywords: acetylation; anticancer; breast cancer; methylation; quercetin; quercetin derivatives
المشرفين على المادة: 9IKM0I5T1E (Quercetin)
0 (Antineoplastic Agents)
0 (Tumor Suppressor Protein p53)
EC 3.4.22.- (Caspase 3)
تواريخ الأحداث: Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11124128
DOI: 10.3390/molecules29102408
PMID: 38792269
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29102408