دورية أكاديمية
أعرض في EDS

Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer.

التفاصيل البيبلوغرافية
العنوان: Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer.
المؤلفون: Jorns JM; Department of Pathology, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Sun Y; Department of Pathology, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Kamaraju S; Division of Hematology and Oncology, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Cheng YC; Division of Hematology and Oncology, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Kong A; Division of Surgical Oncology, Department of Surgery, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Yen T; Division of Surgical Oncology, Department of Surgery, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Patten CR; Division of Surgical Oncology, Department of Surgery, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Cortina CS; Division of Surgical Oncology, Department of Surgery, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Chitambar CR; Division of Hematology and Oncology, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA., Rui H; Department of Pharmacology, Physiology & Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19144, USA.; Sidney Kimmel Cancer Center, Philadelphia, PA 19144, USA., Chaudhary LN; Division of Hematology and Oncology, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA.
المصدر: Journal of personalized medicine [J Pers Med] 2024 Apr 29; Vol. 14 (5). Date of Electronic Publication: 2024 Apr 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: PD-L1 immunohistochemistry (IHC) has become an established method for predicting cancer response to targeted anti-PD1 immunotherapies, including breast cancer (BC). The alternative PD-1 ligand, PD-L2, remains understudied but may be a complementary predictive marker. Prospective analysis of 32 breast cancers revealed divergent expression patterns of PD-L1 and PD-L2. PD-L1-positivity was higher in immune cells than in cancer cells (median = 5.0% vs. 0.0%; p = 0.001), whereas PD-L2-positivity was higher in cancer cells than immune cells (median = 30% vs. 5.0%; p = 0.001). Percent positivity of PD-L1 and PD-L2 were not correlated, neither in cancer cells nor immune cells. Based on a cut-point of ≥1% positivity, ER+ tumors (n = 23) were frequently PD-L2-positive (73.9%), whereas only 40.9% were PD-L1-positive. These data suggest differential control of cellular PD-L1 and PD-L2 expression in BC and a potential role for PD-L2 IHC as a complementary marker to PD-L1 to improve selection of aggressive ER+ BC that may benefit from anti-PD-1 therapy.
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فهرسة مساهمة: Keywords: PD-L1; PD-L2; breast cancer; immune checkpoint inhibition; immunohistochemistry
تواريخ الأحداث: Date Created: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11121947
DOI: 10.3390/jpm14050478
PMID: 38793060
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm14050478