دورية أكاديمية
Chronic HIV Transcription, Translation, and Persistent Inflammation.
| العنوان: | Chronic HIV Transcription, Translation, and Persistent Inflammation. |
|---|---|
| المؤلفون: | Kilroy JM; Department of Virology, Immunology, Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA., Leal AA; Department of Virology, Immunology, Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA., Henderson AJ; Department of Virology, Immunology, Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA.; Department of Medicine and Virology, Immunology, Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA. |
| المصدر: | Viruses [Viruses] 2024 May 09; Vol. 16 (5). Date of Electronic Publication: 2024 May 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | HIV Infections*/virology , HIV Infections*/complications , HIV Infections*/immunology , Inflammation* , HIV-1*/genetics , Transcription, Genetic*, Humans ; Proviruses/genetics ; Protein Biosynthesis ; RNA, Viral/genetics |
| مستخلص: | People with HIV exhibit persistent inflammation that correlates with HIV-associated comorbidities including accelerated aging, increased risk of cardiovascular disease, and neuroinflammation. Mechanisms that perpetuate chronic inflammation in people with HIV undergoing antiretroviral treatments are poorly understood. One hypothesis is that the persistent low-level expression of HIV proviruses, including RNAs generated from defective proviral genomes, drives the immune dysfunction that is responsible for chronic HIV pathogenesis. We explore factors during HIV infection that contribute to the generation of a pool of defective proviruses as well as how HIV-1 mRNA and proteins alter immune function in people living with HIV. |
| References: | Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):. (PMID: 33836568) Pathog Immun. 2020 Jun 17;5(1):143-174. (PMID: 32856008) J Infect Dis. 2004 Jan 15;189(2):273-85. (PMID: 14722893) Nat Commun. 2020 Jan 9;11(1):147. (PMID: 31919342) Nat Commun. 2021 Apr 12;12(1):2187. (PMID: 33846346) J Immunol. 2008 Jan 1;180(1):372-82. (PMID: 18097038) PLoS Pathog. 2021 Feb 26;17(2):e1009364. (PMID: 33635925) Cell Rep. 2019 Apr 30;27(5):1579-1596.e7. (PMID: 31042482) Retrovirology. 2019 Dec 16;16(1):40. (PMID: 31842941) Retrovirology. 2019 Nov 6;16(1):30. (PMID: 31690330) Viruses. 2022 Mar 23;14(4):. (PMID: 35458396) Cell Host Microbe. 2017 Apr 12;21(4):494-506.e4. (PMID: 28407485) Microbiol Immunol. 2019 Feb;63(2):51-64. (PMID: 30677166) Science. 1988 Nov 25;242(4882):1168-71. (PMID: 2460924) Nat Rev Microbiol. 2022 Jan;20(1):20-34. (PMID: 34244677) J Virol. 2019 Oct 15;93(21):. (PMID: 31434734) Retrovirology. 2018 Feb 02;15(1):18. (PMID: 29394935) Nat Med. 2016 Jul;22(7):807-11. (PMID: 27294875) Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27. (PMID: 18594563) J Cell Sci. 2015 Dec 1;128(23):4255-62. (PMID: 26567218) Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8783-8. (PMID: 27432972) Viruses. 2020 May 27;12(6):. (PMID: 32471198) Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. (PMID: 28228523) mBio. 2018 Oct 23;9(5):. (PMID: 30352932) Front Microbiol. 2015 Aug 25;6:878. (PMID: 26379653) Virol J. 2020 Jan 7;17(1):4. (PMID: 31910871) Nat Med. 2016 Sep;22(9):1043-9. (PMID: 27500724) J Virol. 2016 May 27;90(12):5665-5676. (PMID: 27030274) J Virol. 1991 Dec;65(12):7066-72. (PMID: 1942259) PLoS Pathog. 2011 Feb 10;7(2):e1001280. (PMID: 21347347) Front Immunol. 2019 Jul 23;10:1606. (PMID: 31396206) Cell Host Microbe. 2015 Oct 14;18(4):463-70. (PMID: 26468749) Nat Microbiol. 2023 May;8(5):833-844. (PMID: 36973419) Retrovirology. 2022 Sep 16;19(1):21. (PMID: 36114511) Viruses. 2020 May 18;12(5):. (PMID: 32443452) Nat Commun. 2018 Aug 27;9(1):3450. (PMID: 30150664) Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006890. (PMID: 22762018) Int J Mol Sci. 2016 May 06;17(5):. (PMID: 27164092) Nucleic Acids Res. 2005 Aug 01;33(13):4285-310. (PMID: 16061936) Elife. 2020 Jun 15;9:. (PMID: 32538781) Curr Top Microbiol Immunol. 2009;339:177-200. (PMID: 20012529) Science. 2004 Mar 5;303(5663):1526-9. (PMID: 14976262) Viruses. 2022 Dec 21;15(1):. (PMID: 36680071) Cell Rep. 2023 Jun 27;42(6):112556. (PMID: 37227817) Curr Opin HIV AIDS. 2023 Sep 1;18(5):264-272. (PMID: 37535041) J Virol. 2006 May;80(10):4758-70. (PMID: 16641269) Cell. 2021 Feb 18;184(4):1032-1046.e18. (PMID: 33571428) Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2282-2289. (PMID: 30670656) PLoS Pathog. 2019 May 22;15(5):e1007802. (PMID: 31116788) J Virol. 2000 Dec;74(23):11191-200. (PMID: 11070016) Mol Cell. 2018 Jun 7;70(5):961-970.e5. (PMID: 29883611) Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):. (PMID: 33811141) Cell Rep. 2023 Nov 28;42(11):113277. (PMID: 37864791) Viruses. 2024 Jan 16;16(1):. (PMID: 38257827) Annu Rev Virol. 2017 Sep 29;4(1):261-285. (PMID: 28715973) J Virol. 1991 Oct;65(10):5305-13. (PMID: 1895385) PLoS Pathog. 2021 Dec 28;17(12):e1009982. (PMID: 34962974) Transcription. 2019 Apr;10(2):57-75. (PMID: 30227759) J Immunol. 2006 Feb 15;176(4):2470-5. (PMID: 16456007) PLoS Pathog. 2021 Mar 10;17(3):e1009421. (PMID: 33690734) Nat Commun. 2019 Feb 13;10(1):728. (PMID: 30760706) Proc Natl Acad Sci U S A. 2016 May 10;113(19):5311-6. (PMID: 27114546) Cell Rep. 2018 Jun 26;23(13):3741-3749. (PMID: 29949759) Virology. 2003 Sep 15;314(1):460-7. (PMID: 14517098) Science. 2013 Aug 23;341(6148):903-6. (PMID: 23929945) Int Rev Cell Mol Biol. 2019;344:139-172. (PMID: 30798987) Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3364-8. (PMID: 11248084) J Virol. 2005 Mar;79(5):2973-8. (PMID: 15709017) J Gen Virol. 2019 May;100(5):863-876. (PMID: 30896385) J Virol. 2014 Aug;88(16):8924-35. (PMID: 24872592) J Leukoc Biol. 2022 Nov;112(5):1343-1356. (PMID: 35588262) Nature. 2009 Oct 22;461(7267):1071-8. (PMID: 19847258) Viruses. 2021 Dec 14;13(12):. (PMID: 34960781) Annu Rev Med. 2002;53:499-518. (PMID: 11818487) Curr HIV/AIDS Rep. 2022 Jun;19(3):194-206. (PMID: 35404007) JAMA. 1999 Nov 3;282(17):1627-32. (PMID: 10553788) Nat Rev Mol Cell Biol. 2024 Mar;25(3):212-222. (PMID: 37872387) J Virol. 2013 Sep;87(18):10313-23. (PMID: 23678164) mBio. 2023 Aug 31;14(4):e0078923. (PMID: 37404017) Virology. 2002 Aug 15;300(1):100-8. (PMID: 12202210) Retrovirology. 2012 Oct 23;9:87. (PMID: 23092122) Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210. (PMID: 23847781) Science. 2012 Jun 29;336(6089):1719-23. (PMID: 22745432) Cell Rep. 2021 Sep 28;36(13):109763. (PMID: 34592156) J Exp Med. 2001 Sep 17;194(6):863-9. (PMID: 11561001) Retrovirology. 2012 Oct 23;9:88. (PMID: 23092163) Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4571-80. (PMID: 24154727) J Clin Invest. 2021 Feb 1;131(3):. (PMID: 33301425) Viruses. 2024 Jan 11;16(1):. (PMID: 38257808) Virology. 1995 Jan 10;206(1):196-202. (PMID: 7831774) Front Immunol. 2023 May 23;14:1150705. (PMID: 37287967) AIDS Rev. 2022;25(2):79-86. (PMID: 35901108) Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12209-14. (PMID: 11593039) J Biol Chem. 2015 Jul 10;290(28):17380-9. (PMID: 26032416) J Virol. 2020 Dec 9;95(5):. (PMID: 33298546) Cell. 2013 Oct 24;155(3):540-51. (PMID: 24243014) Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3704-3710. (PMID: 32029589) Nat Med. 2012 Nov;18(11):1682-7. (PMID: 22972397) Front Genet. 2016 Aug 09;7:147. (PMID: 27555866) Curr Opin HIV AIDS. 2016 Mar;11(2):173-81. (PMID: 26628325) Nat Rev Immunol. 2019 Aug;19(8):477-489. (PMID: 31036962) Nature. 2000 Apr 13;404(6779):770-4. (PMID: 10783891) J Virol. 2012 Aug;86(15):7790-805. (PMID: 22593154) mBio. 2020 Aug 4;11(4):. (PMID: 32753492) Cell Rep. 2022 May 24;39(8):110840. (PMID: 35613597) Nature. 2023 Aug;620(7976):1025-1030. (PMID: 37532928) Cold Spring Harb Perspect Med. 2012 Oct 01;2(10):. (PMID: 23028129) Front Immunol. 2022 Dec 07;13:1017164. (PMID: 36569826) Viruses. 2021 Jun 17;13(6):. (PMID: 34204384) Nature. 2011 May 25;474(7353):654-7. (PMID: 21613998) Retrovirology. 2018 Jan 16;15(1):8. (PMID: 29338752) Nat Immunol. 2015 Jun;16(6):554-62. (PMID: 25988887) Curr Pharm Des. 2017;23(28):4098-4102. (PMID: 28677507) Virology. 2015 May;479-480:131-45. (PMID: 25818029) Nat Struct Mol Biol. 2016 Oct;23(10):933-940. (PMID: 27571178) Cytokine Growth Factor Rev. 2018 Apr;40:68-76. (PMID: 29548644) Nat Immunol. 2012 Feb 12;13(3):223-228. (PMID: 22327569) Front Microbiol. 2021 Mar 18;12:636642. (PMID: 33868195) J Virol. 2012 Apr;86(7):3777-86. (PMID: 22301159) Front Immunol. 2017 Oct 06;8:1246. (PMID: 29056936) Viruses. 2020 Jun 30;12(7):. (PMID: 32630058) J Leukoc Biol. 2013 Aug;94(2):337-41. (PMID: 23744645) J Leukoc Biol. 2000 Sep;68(3):303-10. (PMID: 10985244) Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4130-5. (PMID: 17360488) J Virol. 1990 Nov;64(11):5448-56. (PMID: 2214021) J Clin Invest. 2020 Nov 2;130(11):5665-5667. (PMID: 33016925) Viruses. 2021 Apr 29;13(5):. (PMID: 33946840) J Virol. 2010 Oct;84(19):9864-78. (PMID: 20660205) Front Microbiol. 2021 Apr 07;12:646447. (PMID: 33897659) Curr Opin Immunol. 2022 Oct;78:102250. (PMID: 36209576) Nature. 2011 Jun 29;474(7353):658-61. (PMID: 21720370) J Clin Invest. 2023 Mar 15;133(6):. (PMID: 36602866) Nature. 2011 Nov 06;480(7377):379-82. (PMID: 22056990) Molecules. 2020 Feb 14;25(4):. (PMID: 32075058) J Immunol Res. 2021 Sep 20;2021:1487287. (PMID: 34595244) Nat Commun. 2018 Dec 13;9(1):5305. (PMID: 30546110) Cell Host Microbe. 2021 May 12;29(5):792-805.e6. (PMID: 33811831) J Biol Chem. 2016 Aug 12;291(33):16936-16947. (PMID: 27354282) J Virol. 2013 Jan;87(1):257-72. (PMID: 23077300) Front Microbiol. 2014 Apr 22;5:176. (PMID: 24795708) Cytokine Growth Factor Rev. 2018 Apr;40:19-31. (PMID: 29576284) Immunity. 2013 Oct 17;39(4):633-45. (PMID: 24138880) Science. 2021 Mar 19;371(6535):. (PMID: 33542150) EMBO J. 2001 Jun 15;20(12):3272-81. (PMID: 11406603) Front Immunol. 2023 Feb 28;14:1132653. (PMID: 36926349) Cell Mol Life Sci. 2018 Jul;75(14):2491-2507. (PMID: 29417178) Retrovirology. 2011 Apr 13;8:25. (PMID: 21489275) Viruses. 2023 Jul 31;15(8):. (PMID: 37632019) J Immunol. 2022 Sep 1;209(5):864-873. (PMID: 36130133) J Leukoc Biol. 2023 Jul 1;114(1):53-67. (PMID: 36976024) AIDS. 2014 Sep 24;28(15):2175-87. (PMID: 25144219) PLoS One. 2012;7(1):e29291. (PMID: 22235281) PLoS Pathog. 2007 Jul;3(7):e85. (PMID: 17630831) Nat Commun. 2021 Jun 17;12(1):3691. (PMID: 34140527) Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3921-30. (PMID: 27335459) Cell Host Microbe. 2015 Jun 10;17(6):736-40. (PMID: 26067601) J Exp Med. 2010 Jan 18;207(1):51-9. (PMID: 20065064) Curr Opin HIV AIDS. 2022 Sep 1;17(5):286-292. (PMID: 35938462) |
| معلومات مُعتمدة: | DA055488 National Institute of Health; AI138960 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: HIV; defective proviruses; inflammation; persistence; transcription |
| المشرفين على المادة: | 0 (RNA, Viral) |
| تواريخ الأحداث: | Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240528 |
| رمز التحديث: | 20240528 |
| مُعرف محوري في PubMed: | PMC11125830 |
| DOI: | 10.3390/v16050751 |
| PMID: | 38793632 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1999-4915 |
|---|---|
| DOI: | 10.3390/v16050751 |