دورية أكاديمية
Therapeutic Effects of Essential Oils and Their Bioactive Compounds on Prostate Cancer Treatment.
العنوان: | Therapeutic Effects of Essential Oils and Their Bioactive Compounds on Prostate Cancer Treatment. |
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المؤلفون: | Pimentel LS; Laboratory of Nanobiotechnology Professor Luiz Ricardo Goulart Filho, Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, Bloco 2E, Sala 248, Uberlândia 38405-302, MG, Brazil., Bastos LM; Laboratory of Nanobiotechnology Professor Luiz Ricardo Goulart Filho, Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, Bloco 2E, Sala 248, Uberlândia 38405-302, MG, Brazil., Goulart LR; Laboratory of Nanobiotechnology Professor Luiz Ricardo Goulart Filho, Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, Bloco 2E, Sala 248, Uberlândia 38405-302, MG, Brazil., Ribeiro LNM; Laboratory of Nanobiotechnology Professor Luiz Ricardo Goulart Filho, Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, Bloco 2E, Sala 248, Uberlândia 38405-302, MG, Brazil. |
المصدر: | Pharmaceutics [Pharmaceutics] 2024 Apr 24; Vol. 16 (5). Date of Electronic Publication: 2024 Apr 24. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مستخلص: | Since prostate cancer (PCa) relies on limited therapies, more effective alternatives are required. Essential oils (EOs) and their bioactive compounds are natural products that have many properties including anticancer activity. This review covers studies published between 2000 and 2023 and discusses the anti-prostate cancer mechanisms of the EOs from several plant species and their main bioactive compounds. It also provides a critical perspective regarding the challenges to be overcome until they reach the market. EOs from chamomile, cinnamon, Citrus species, turmeric, Cymbopogon species, ginger, lavender, Mentha species, rosemary, Salvia species, thyme and other species have been tested in different PCa cell lines and have shown excellent results, including the inhibition of cell growth and migration, the induction of apoptosis, modulation in the expression of apoptotic and anti-apoptotic genes and the suppression of angiogenesis. The most challenging aspects of EOs, which limit their clinical uses, are their highly lipophilic nature, physicochemical instability, photosensitivity, high volatility and composition variability. The processing of EO-based products in the pharmaceutical field may be an interesting alternative to circumvent EOs' limitations, resulting in several benefits in their further clinical use. Identifying their bioactive compounds, therapeutic effects and chemical structures could open new perspectives for innovative developments in the field. Moreover, this could be helpful in obtaining versatile chemical synthesis routes and/or biotechnological drug production strategies, providing an accurate, safe and sustainable source of these bioactive compounds, while looking at their use as gold-standard therapy in the close future. |
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فهرسة مساهمة: | Keywords: essential oil; natural products; natural treatment; prostate cancer |
تواريخ الأحداث: | Date Created: 20240525 Latest Revision: 20240527 |
رمز التحديث: | 20240527 |
مُعرف محوري في PubMed: | PMC11125265 |
DOI: | 10.3390/pharmaceutics16050583 |
PMID: | 38794244 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1999-4923 |
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DOI: | 10.3390/pharmaceutics16050583 |