دورية أكاديمية
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Daily Consumption of α-Linolenic Acid Increases Conversion Efficiency to Eicosapentaenoic Acid in Mice.

التفاصيل البيبلوغرافية
العنوان: Daily Consumption of α-Linolenic Acid Increases Conversion Efficiency to Eicosapentaenoic Acid in Mice.
المؤلفون: Watabe S; Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai Nishi, Miyazaki 889-2192, Japan., Tanaka W; Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai Nishi, Miyazaki 889-2192, Japan., Sakakibara H; Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai Nishi, Miyazaki 889-2192, Japan.; Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan., Yokoyama D; Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai Nishi, Miyazaki 889-2192, Japan.
المصدر: Nutrients [Nutrients] 2024 May 07; Vol. 16 (10). Date of Electronic Publication: 2024 May 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: alpha-Linolenic Acid*/administration & dosage , Eicosapentaenoic Acid*/blood , Eicosapentaenoic Acid*/administration & dosage , Mice, Inbred C57BL* , Mice, Inbred ICR* , Plant Oils*/administration & dosage , Liver*/metabolism, Animals ; Male ; Mice ; Fatty Acid Elongases/metabolism ; Olive Oil/administration & dosage ; Acetyltransferases/metabolism ; Acetyltransferases/genetics
مستخلص: To maintain a beneficial concentration of eicosapentaenoic acid (EPA), the efficient conversion of its precursor, α-linolenic acid (α-LA), is important. Here, we studied the conversion of α-LA to EPA using ICR and C57BL/6 mice. A single dose of perilla oil rich-in α-LA or free α-LA had not been converted to EPA 18 h following administration. The α-LA was absorbed into the circulation, and its concentration peaked 6 h after administration, after which it rapidly decreased. In contrast, EPA administration was followed by an increase in circulating EPA concentration, but this did not decrease between 6 and 18 h, indicating that the clearance of EPA is slower than that of α-LA. After ≥1 week perilla oil intake, the circulating EPA concentration was >20 times higher than that of the control group which consumed olive oil, indicating that daily consumption, but not a single dose, of α-LA-rich oil might help preserve the physiologic EPA concentration. The consumption of high concentrations of perilla oil for 4 weeks also increased the hepatic expression of Elovl5 , which is involved in fatty acid elongation; however, further studies are needed to characterize the relationship between the expression of this gene and the conversion of α-LA to EPA.
References: Br J Nutr. 2002 Oct;88(4):355-63. (PMID: 12323085)
Int J Vitam Nutr Res. 1998;68(3):159-73. (PMID: 9637947)
Molecules. 2022 Feb 14;27(4):. (PMID: 35209062)
Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):85-91. (PMID: 19269799)
PLoS One. 2020 Oct 6;15(10):e0235875. (PMID: 33022003)
Lipids. 1987 Oct;22(10):711-4. (PMID: 2828810)
Genes Nutr. 2014 Nov;9(6):437. (PMID: 25367143)
Nutrients. 2023 Nov 26;15(23):. (PMID: 38068783)
J Lipid Res. 2008 Jul;49(7):1538-52. (PMID: 18376007)
Br J Nutr. 2019 Jan;121(2):137-145. (PMID: 30507367)
J Lipid Res. 2005 Feb;46(2):269-80. (PMID: 15576848)
Pharmacol Res Perspect. 2019 Mar 09;7(2):e00465. (PMID: 30899516)
Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):137-41. (PMID: 20638827)
Nutrients. 2023 Feb 01;15(3):. (PMID: 36771455)
J Lipid Res. 2005 Jul;46(7):1474-83. (PMID: 15834128)
Nutrients. 2023 Oct 13;15(20):. (PMID: 37892438)
J Lipid Res. 2003 Mar;44(3):455-63. (PMID: 12562865)
J Lipid Res. 2018 Dec;59(12):2383-2396. (PMID: 30293059)
Nutr Res Pract. 2013 Aug;7(4):256-61. (PMID: 23964311)
J Mol Cell Cardiol. 2017 Feb;103:74-92. (PMID: 27986444)
Trends Biochem Sci. 2002 Sep;27(9):467. (PMID: 12217522)
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1538-44. (PMID: 18573585)
Prog Lipid Res. 2016 Oct;64:30-56. (PMID: 27496755)
Reprod Nutr Dev. 2005 Sep-Oct;45(5):581-97. (PMID: 16188209)
Nutrients. 2019 Mar 29;11(4):. (PMID: 30934976)
Nutrients. 2023 Nov 18;15(22):. (PMID: 38004225)
Food Nutr Res. 2014 Jul 10;58:. (PMID: 25045347)
Lipids Health Dis. 2018 Jul 18;17(1):162. (PMID: 30021606)
J Nutr. 2011 Feb;141(2):207-13. (PMID: 21178084)
Mediators Inflamm. 2021 Jan 2;2021:8879227. (PMID: 33488295)
Life Sci. 2018 Jun 15;203:255-267. (PMID: 29715470)
Molecules. 2021 Jul 08;26(14):. (PMID: 34299426)
Adv Nutr. 2012 Jan;3(1):1-7. (PMID: 22332096)
معلومات مُعتمدة: 21H03361 Japan Society for the Promotion of Science; 22KJ2525 Japan Society for the Promotion of Science
فهرسة مساهمة: Keywords: daily consumption; eicosapentaenoic acid; mouse; α-linolenic acid; ω-3 fatty acid
المشرفين على المادة: 0RBV727H71 (alpha-Linolenic Acid)
AAN7QOV9EA (Eicosapentaenoic Acid)
68132-21-8 (perilla seed oil)
0 (Plant Oils)
EC 2.3.1.- (Fatty Acid Elongases)
0 (Olive Oil)
EC 2.3.1.- (Acetyltransferases)
تواريخ الأحداث: Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11124506
DOI: 10.3390/nu16101407
PMID: 38794645
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16101407