دورية أكاديمية
Oral Candida albicans strain diversity and maintenance in HIV positive women in South Africa.
| العنوان: | Oral Candida albicans strain diversity and maintenance in HIV positive women in South Africa. |
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| المؤلفون: | Owotade FJ; Department of Clinical Microbiology and Infectious Diseases, School of Pathology, South Africa; Faculty of Dentistry, Obafemi Awolowo University, Ile-Ife, Nigeria., Gulube Z; Department of Oral Biological Sciences School of Oral Health Sciences, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg, South Africa., Patel M; Department of Clinical Microbiology and Infectious Diseases, School of Pathology, South Africa. Electronic address: Mrudula.patel@wits.ac.za. |
| المصدر: | Archives of oral biology [Arch Oral Biol] 2024 Aug; Vol. 164, pp. 106007. Date of Electronic Publication: 2024 May 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Pergamon Press Original Publication: Oxford, New York [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Candida albicans*/genetics , Candida albicans*/isolation & purification , Multilocus Sequence Typing* , Candidiasis, Oral*/microbiology , Genotype*, Humans ; Female ; South Africa ; Adult ; HIV Infections/microbiology ; Mouth/microbiology ; Genetic Variation ; Mycological Typing Techniques/methods ; Middle Aged |
| مستخلص: | Objective: This study investigated C. albicans strain diversity and maintenance in the oral cavity of HIV positive women over a 6 month period. Study Design: C. albicans strains were isolated from 17 HIV positive women at Charlotte Maxeke Academic Hospital, Johannesburg at 3 intervals over a 6 month period. Strains were genotyped using ABC and Multilocus Sequence Typing (MLST) techniques. In the MLST technique, for each strain, a Diploid Sequence Type (DST) number was obtained. Using cluster analysis, an Unweighted Pair Group Method with Arithmetic Mean (UPGMA) dendrogram and a matrix of strain similarities were generated. Strains were also compared to the previous South African isolates documented in the MLST database. Results: Ninety four percent of women carried the same ABC genotype for 6 months. MLST technique, showed that ten women (58.8%) carried the same DST at 2 visits, while seven (41.2%) carried different DST at all visits. Further analysis showed that 64.7% of women were recolonised with different strains and 35.3% carried the same strains of C. albicans with heterozygosity. A total of 40 diploid sequence types were identified of which 27 DSTs were unique to this study group that were added to the MLST database. Most of the strains were closely related to previously isolated strains from South Africa. Conclusion: Recolonization of the oral cavity with different strains and microevolution of the original strains of C. albicans can occur, which can be a potential problem for HIV patients, in whom highly virulent and drug resistant strains can emerge. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Candida albicans; Genotyping; HIV, ABC genotyping; Multilocus sequence typing; Oral |
| تواريخ الأحداث: | Date Created: 20240525 Date Completed: 20240604 Latest Revision: 20240604 |
| رمز التحديث: | 20240605 |
| DOI: | 10.1016/j.archoralbio.2024.106007 |
| PMID: | 38795522 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-1506 |
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| DOI: | 10.1016/j.archoralbio.2024.106007 |