دورية أكاديمية
أعرض في EDS

Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa.

التفاصيل البيبلوغرافية
العنوان: Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa.
المؤلفون: Hasken JM; University of North Carolina at Chapel Hill, Nutrition Research Institute, USA. Electronic address: jhasken@email.unc.edu., de Vries MM; Stellenbosch University, Faculty of Medicine and Health Sciences, USA., Marais AS; Stellenbosch University, Faculty of Medicine and Health Sciences, USA., May PA; University of North Carolina at Chapel Hill, Nutrition Research Institute, USA; Stellenbosch University, Faculty of Medicine and Health Sciences, USA; University of New Mexico, Center on Alcohol, Substance Use, and Additions, USA.
المصدر: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2024 Aug; Vol. 127, pp. 108606. Date of Electronic Publication: 2024 May 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Elmsford Ny : Pergamon In Cooperation With The Reproductive Toxicology Center
Original Publication: Elmsford, N.Y., U.S.A. : Pergamon Press, c1987-
مواضيع طبية MeSH: Zinc*/blood , Ferritins*/blood , Prenatal Exposure Delayed Effects*/blood , Alcohol Drinking*/blood, Humans ; Female ; Pregnancy ; South Africa/epidemiology ; Adult ; Infant ; Young Adult ; Male ; Aspartate Aminotransferases/blood ; Nutritional Status ; Iron/blood ; Alanine Transaminase/blood ; Ethanol/blood
مستخلص: Nutritional status during pregnancy can impact fetal development, yet less is known about how alcohol may interact with nutritional status to influence infant outcomes. Pregnant women (n=196) completed 2, 24-hour dietary recalls and provided a venous blood sample to be analyzed for liver enzymes (GGT -gamma-glutamyl transferase; ALT -alanine transaminase; and AST -aspartate transferase), iron, ferritin, and zinc concentrations. Infants were assessed at 6 weeks of age. Women who consumed alcohol had significantly higher ferritin levels compared to non-drinkers (51.8 vs. 34.2). While 44% of women had ferritin <30 ug/L (an indicator of iron deficiency), and 24% of women were low in serum iron, and 72% were low in serum zinc. All six drinking measures for 1st trimester and previous week were significantly correlated with GGT and AST levels while 4 out of 6 alcohol measures were associated with levels of ALT and ferritin. At six weeks of age, nearly all physical measures differentiated infants with alcohol exposure from infants without exposure. Controlling for six covariates, maternal ferritin was significantly and inversely associated with infant head circumference (OFC) centile among infants with alcohol exposure. GGT was inversely associated with infant height and weight centile among unexposed infants. Seventy-four percent (74%) of mothers who consumed alcohol were found to be low in serum zinc, yet higher maternal zinc was associated with more dysmorphology. This may indicate that higher zinc status is not protecting the fetus from the teratogenic effects of alcohol. Prenatal alcohol exposure, ferritin, and zinc status influence infant growth and neurodevelopment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
References: Nutr Rev. 2011 Nov;69 Suppl 1:S23-9. (PMID: 22043878)
Lancet. 2016 Feb 27;387(10021):907-16. (PMID: 26314490)
Reprod Toxicol. 2014 Jul;46:31-9. (PMID: 24568797)
J Am Coll Surg. 2012 Oct;215(4):475-9. (PMID: 22770864)
J Lab Clin Med. 1982 Jul;100(1):45-52. (PMID: 7086268)
Lancet. 1981 Mar 14;1(8220 Pt 1):572-51. (PMID: 6110817)
Alcohol Clin Exp Res. 1983 Winter;7(1):5-10. (PMID: 6342450)
Reprod Toxicol. 2016 Jan;59:101-8. (PMID: 26656914)
Free Radic Biol Med. 2004 Oct 1;37(7):1018-23. (PMID: 15336318)
Atherosclerosis. 2005 Feb;178(2):327-30. (PMID: 15694941)
World J Gastroenterol. 2005 Dec 7;11(45):7109-17. (PMID: 16437656)
Med Arch. 2016 Feb;70(1):44-7. (PMID: 26980931)
J Am Diet Assoc. 2010 Apr;110(4):551-62. (PMID: 20338281)
N Engl J Med. 2015 May 7;372(19):1832-43. (PMID: 25946282)
Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):193-7. (PMID: 15499043)
Nutrients. 2022 Oct 21;14(20):. (PMID: 36297115)
J Trace Elem Med Biol. 2010 Jul;24(3):200-6. (PMID: 20507833)
Alcohol Clin Exp Res (Hoboken). 2023 May;47(5):848-855. (PMID: 36871954)
J Nutr. 2016 Jun;146(6):1180-8. (PMID: 27146918)
Pediatr Res. 1983 Jul;17(7):529-31. (PMID: 6622095)
Alcohol Clin Exp Res. 2009 Apr;33(4):591-600. (PMID: 19183140)
Alcohol Clin Exp Res. 2022 Oct;46(10):1819-1836. (PMID: 35971629)
Neurotoxicol Teratol. 2013 Sep-Oct;39:128-32. (PMID: 23871794)
Pediatrics. 2019 Dec;144(6):. (PMID: 31744890)
J Am Coll Surg. 2011 Feb;212(2):209-14. (PMID: 21183366)
Alcohol Clin Exp Res. 2015 Nov;39(11):2097-107. (PMID: 26399568)
Reprod Toxicol. 2018 Apr;77:25-32. (PMID: 29425712)
PLoS One. 2012;7(10):e47499. (PMID: 23094056)
Curr Res Toxicol. 2022 May 20;3:100076. (PMID: 35694418)
Alcohol Clin Exp Res. 2012 Nov;36(11):1973-82. (PMID: 22897691)
JAMA. 2018 Feb 6;319(5):474-482. (PMID: 29411031)
Pediatr Res. 1985 Sep;19(9):944-7. (PMID: 4047764)
MMWR Morb Mortal Wkly Rep. 2020 Aug 07;69(31):1009-1014. (PMID: 32759915)
Pediatrics. 2007 Sep;120(3):559-67. (PMID: 17766529)
Drug Alcohol Depend. 2021 Jan 1;218:108408. (PMID: 33250379)
J Pediatr. 1987 Aug;111(2):267-8. (PMID: 3612403)
Pharmacol Biochem Behav. 1983;18 Suppl 1:311-5. (PMID: 6634846)
J Nutr. 1981 Nov;111(11):2034-8. (PMID: 7197711)
Am J Clin Nutr. 2021 Sep 1;114(3):1107-1122. (PMID: 34091657)
Pediatrics. 1968 Jan;41(1):106-14. (PMID: 5635472)
Curr Res Toxicol. 2023 Apr 05;4:100105. (PMID: 37102125)
معلومات مُعتمدة: F32 AA030495 United States AA NIAAA NIH HHS; R01 AA015134 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: Ferritin; Fetal alcohol spectrum disorders; Prenatal alcohol exposure; Zinc
المشرفين على المادة: J41CSQ7QDS (Zinc)
9007-73-2 (Ferritins)
EC 2.6.1.1 (Aspartate Aminotransferases)
E1UOL152H7 (Iron)
EC 2.6.1.2 (Alanine Transaminase)
3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20240525 Date Completed: 20240614 Latest Revision: 20240816
رمز التحديث: 20240816
مُعرف محوري في PubMed: PMC11325234
DOI: 10.1016/j.reprotox.2024.108606
PMID: 38795788
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1708
DOI:10.1016/j.reprotox.2024.108606