دورية أكاديمية
Lipidome atlas of the adult human brain.
| العنوان: | Lipidome atlas of the adult human brain. |
|---|---|
| المؤلفون: | Osetrova M; Skolkovo Institute of Science and Technology, Moscow, Russia., Tkachev A; Skolkovo Institute of Science and Technology, Moscow, Russia., Mair W; Skolkovo Institute of Science and Technology, Moscow, Russia., Guijarro Larraz P; Skolkovo Institute of Science and Technology, Moscow, Russia., Efimova O; Skolkovo Institute of Science and Technology, Moscow, Russia., Kurochkin I; Skolkovo Institute of Science and Technology, Moscow, Russia., Stekolshchikova E; Skolkovo Institute of Science and Technology, Moscow, Russia., Anikanov N; Skolkovo Institute of Science and Technology, Moscow, Russia., Foo JC; Singapore Lipidomics Incubator, Life Sciences Institute and Precision Medicine Translational Research Program, Department of Biochemistry, Yong Loo Lin School of Medicine; National University of Singapore, Singapore, Singapore., Cazenave-Gassiot A; Singapore Lipidomics Incubator, Life Sciences Institute and Precision Medicine Translational Research Program, Department of Biochemistry, Yong Loo Lin School of Medicine; National University of Singapore, Singapore, Singapore., Mitina A; Skolkovo Institute of Science and Technology, Moscow, Russia., Ogurtsova P; Skolkovo Institute of Science and Technology, Moscow, Russia., Guo S; Skolkovo Institute of Science and Technology, Moscow, Russia., Potashnikova DM; Department of Cell Biology and Histology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia., Gulin AA; N. N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences, Moscow, Russia., Vasin AA; N. N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences, Moscow, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Sarycheva A; Skolkovo Institute of Science and Technology, Moscow, Russia., Vladimirov G; Skolkovo Institute of Science and Technology, Moscow, Russia., Fedorova M; Leipzig University, Leipzig, Germany., Kostyukevich Y; Skolkovo Institute of Science and Technology, Moscow, Russia., Nikolaev E; Skolkovo Institute of Science and Technology, Moscow, Russia., Wenk MR; Singapore Lipidomics Incubator, Life Sciences Institute and Precision Medicine Translational Research Program, Department of Biochemistry, Yong Loo Lin School of Medicine; National University of Singapore, Singapore, Singapore. bchmrw@nus.edu.sg., Khrameeva EE; Skolkovo Institute of Science and Technology, Moscow, Russia. e.khrameeva@skoltech.ru., Khaitovich P; Skolkovo Institute of Science and Technology, Moscow, Russia. p.khaitovich@skoltech.ru. |
| المصدر: | Nature communications [Nat Commun] 2024 May 25; Vol. 15 (1), pp. 4455. Date of Electronic Publication: 2024 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Lipidomics* , Brain*/metabolism , Lipids*/chemistry , Lipids*/analysis, Humans ; Animals ; Mice ; Adult ; Male ; Lipid Metabolism ; Macaca ; Neurons/metabolism ; Female ; Fatty Acids, Omega-3/metabolism ; Fatty Acids, Omega-6/metabolism ; Myelin Sheath/metabolism ; Middle Aged |
| مستخلص: | Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain's structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 22-15-00474 Russian Science Foundation (RSF); 21-74-10102 Russian Science Foundation (RSF) |
| المشرفين على المادة: | 0 (Lipids) 0 (Fatty Acids, Omega-3) 0 (Fatty Acids, Omega-6) |
| تواريخ الأحداث: | Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240528 |
| رمز التحديث: | 20240528 |
| مُعرف محوري في PubMed: | PMC11127996 |
| DOI: | 10.1038/s41467-024-48734-y |
| PMID: | 38796479 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-48734-y |