دورية أكاديمية
Detection of early metaphyseal changes in a piglet model of Legg-Calvé-Perthes disease using quantitative mapping of MRI relaxation times.
| العنوان: | Detection of early metaphyseal changes in a piglet model of Legg-Calvé-Perthes disease using quantitative mapping of MRI relaxation times. |
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| المؤلفون: | Buko EO; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA.; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA., Armstrong AR; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA., Laine JC; Gillette Children's Specialty Healthcare, St. Paul, Minnesota, USA.; Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA., Tóth F; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA., Johnson CP; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA.; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA. |
| المصدر: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 May 26. Date of Electronic Publication: 2024 May 26. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8404726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-527X (Electronic) Linking ISSN: 07360266 NLM ISO Abbreviation: J Orthop Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2006- : Hoboken, NJ : Wiley Original Publication: New York, N.Y. : Raven Press, [c1983- |
| مستخلص: | Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder characterized by ischemic injury to the epiphysis of the femoral head, but changes to the metaphysis have also been implicated in its pathogenesis. Quantitative magnetic resonance imaging (MRI) relaxation time mapping techniques are potentially useful to detect injury in LCPD, but studies to date have focused on the epiphysis. The purpose of this study was to assess whether T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation times can detect early metaphyseal changes in an LCPD piglet model. Complete epiphyseal ischemia of one femoral head was surgically induced and confirmed using contrast-enhanced MRI in n = 10 6-week-old piglets; the contralateral side was unoperated. The bilateral hips were imaged 1 week after surgery in vivo at 3T MRI using relaxation time mapping and contrast-enhanced MRI. Relaxation times and thicknesses of the metaphyseal primary and secondary spongiosa were measured and compared between the ischemic and contralateral-control femoral heads using paired t-tests. In the ischemic femoral heads, T2 relaxation times were significantly increased in the primary spongiosa (6.7 ± 9.8 ms, p = 0.029), and T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation times were significantly decreased in the secondary spongiosa (respectively: -13.3 ± 9.3 ms, p = 0.013; -32 ± 23 ms, p < 0.001; -43 ± 41 ms, p = 0.009; and -39 ± 13 ms, p < 0.001). The secondary spongiosa thickness was also significantly decreased in the ischemic femoral heads (p < 0.001). In conclusion, T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation time mapping techniques can detect early changes in the metaphysis following ischemic injury to the epiphysis of the femoral head in a piglet model of LCPD. (© 2024 The Author(s). Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.) |
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| معلومات مُعتمدة: | R56AR078315 United States AR NIAMS NIH HHS; P41EB027061 United States EB NIBIB NIH HHS; UL1TR002494 United States TR NCATS NIH HHS; L40 AR079814 United States AR NIAMS NIH HHS; K01AR070894 United States AR NIAMS NIH HHS; K01 OD034070 United States OD NIH HHS |
| فهرسة مساهمة: | Keywords: Legg‐Calvé‐Perthes disease (LCPD); growth plate; magnetic resonance imaging; metaphysis; spongiosa |
| تواريخ الأحداث: | Date Created: 20240526 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| DOI: | 10.1002/jor.25904 |
| PMID: | 38796746 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1554-527X |
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| DOI: | 10.1002/jor.25904 |