دورية أكاديمية
Activity of ventral hippocampal parvalbumin interneurons during anxiety.
| العنوان: | Activity of ventral hippocampal parvalbumin interneurons during anxiety. |
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| المؤلفون: | Volitaki E; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Forro T; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Li K; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Nevian T; Neuronal Plasticity Group, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Ciocchi S; Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland. Electronic address: stephane.ciocchi@unibe.ch. |
| المصدر: | Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114295. Date of Electronic Publication: 2024 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Interneurons*/metabolism , Parvalbumins*/metabolism , Anxiety*/metabolism , Hippocampus*/metabolism , Pyramidal Cells*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Optogenetics |
| مستخلص: | Anxiety plays a key role in guiding behavior in response to potential threats. Anxiety is mediated by the activation of pyramidal neurons in the ventral hippocampus (vH), whose activity is controlled by GABAergic inhibitory interneurons. However, how different vH interneurons might contribute to anxiety-related processes is unclear. Here, we investigate the role of vH parvalbumin (PV)-expressing interneurons while mice transition from safe to more anxiogenic compartments of the elevated plus maze (EPM). We find that vH PV interneurons increase their activity in anxiogenic EPM compartments concomitant with dynamic changes in inhibitory interactions between PV interneurons and pyramidal neurons. By optogenetically inhibiting PV interneurons, we induce an increase in the activity of vH pyramidal neurons and persistent anxiety. Collectively, our results suggest that vH inhibitory microcircuits may act as a trigger for enduring anxiety states. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CP: Neuroscience; PV inhibition; anxiety-related activity; interneuron-pyramidal neuron interactions; persistent anxiety; ventral hippocampus PV interneurons |
| المشرفين على المادة: | 0 (Parvalbumins) |
| تواريخ الأحداث: | Date Created: 20240526 Date Completed: 20240701 Latest Revision: 20240701 |
| رمز التحديث: | 20240702 |
| DOI: | 10.1016/j.celrep.2024.114295 |
| PMID: | 38796850 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2024.114295 |