Dynamics of transcription is affected by oxygen tension and developmental speed during in vitro production of bovine embryos.

التفاصيل البيبلوغرافية
العنوان:	Dynamics of transcription is affected by oxygen tension and developmental speed during in vitro production of bovine embryos.
المؤلفون:	de Lima CB; Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Département des Sciences Animales, Université Laval, Quebec, Quebec, Canada.; Laboratory of Embryonic Metabolism and Epigenetic, Center of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., do Amaral DT; Center of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., Ispada J; Laboratory of Embryonic Metabolism and Epigenetic, Center of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., Dos Santos ÉC; Laboratory of Embryonic Metabolism and Epigenetic, Center of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., Fontes PK; Laboratory of Embryonic Metabolism and Epigenetic, Center of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., Nogueira MFG; Department of Biological Sciences, School of Sciences and Languages, São Paulo State University, Campus Assis, Assis, SP, Brazil., Milazzotto MP; Laboratory of Embryonic Metabolism and Epigenetic, Center of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil.
المصدر:	Reproduction in domestic animals = Zuchthygiene [Reprod Domest Anim] 2024 May; Vol. 59 (5), pp. e14620.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Paul Parey Scientific Publishers Country of Publication: Germany NLM ID: 9015668 Publication Model: Print Cited Medium: Internet ISSN: 1439-0531 (Electronic) Linking ISSN: 09366768 NLM ISO Abbreviation: Reprod Domest Anim Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin ; Hamburg : Paul Parey Scientific Publishers, c1990-
مواضيع طبية MeSH:	Oxygen/metabolism , Embryonic Development , Gene Expression Regulation, Developmental* , Embryo Culture Techniques/veterinary , Blastocyst/metabolism, Animals ; Cattle/embryology ; Transcription, Genetic ; Fertilization in Vitro/veterinary ; Female
مستخلص:	This study examines the impact of oxygen tension and embryo kinetics on gene transcription dynamics in pathways crucial for embryonic preimplantation development, including lipid metabolism, carbohydrate transport and metabolism, mitochondrial function, stress response, apoptosis and transcription regulation. Bovine embryos were generated in vitro and allocated into two groups based on oxygen tension (20% or 5%) at 18 h post insemination (hpi). At 40 hpi, embryos were categorized into Fast (≥4 cells) or Slow (2 cells) groups, resulting in four experimental groups: FCL20, FCL5, SCL20 and SCL5. Embryo collection also occurred at 72 hpi (16-cell stage; groups FMO20, FMO5, SMO20 and SMO5) and at 168 hpi (expanded blastocyst (BL) stage; groups FBL20, FBL5, SBL20 and SBL5). Pools of three embryos per group were analysed in four replicates using inventoried TaqMan assays specific for Bos taurus, targeting 93 genes. Gene expression patterns were analysed using the K-means algorithm, revealing three main clusters: genes with low relative abundance at the cleavage (CL) and 16-cell morula (MO) stages but increased at the BL stage (cluster 1); genes with higher abundances at CL but decreasing at MO and BL (cluster 2); and genes with low levels at CL, higher levels at MO and decreased levels at BL (cluster 3). Within each cluster, genes related to epigenetic mechanisms, cell differentiation events and glucose metabolism were particularly influenced by differences in developmental kinetics and oxygen tension. Fast-developing embryos, particularly those cultured under low oxygen tension, exhibited transcript dynamics more closely resembling that reported in vivo-produced embryos. (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة:	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 2015/03381-0 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2017/18384-0 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة:	Keywords: bovine; development; embryo; oxygen tension
المشرفين على المادة:	S88TT14065 (Oxygen)
تواريخ الأحداث:	Date Created: 20240527 Date Completed: 20240527 Latest Revision: 20240527
رمز التحديث:	20240527
DOI:	10.1111/rda.14620
PMID:	38798166
قاعدة البيانات:	MEDLINE

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تدمد:	1439-0531
DOI:	10.1111/rda.14620