Placental Malaria Induces a Unique Placental Methylation Profile Associated with Fetal Growth Restriction.
| العنوان: | Placental Malaria Induces a Unique Placental Methylation Profile Associated with Fetal Growth Restriction. |
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| المؤلفون: | Ozarslan N, Mong C, Ategeka J, Li L, Buarpung S, Robinson JF, Kizza J, Kakuru A, Kamya MR, Dorsey G, Rosenthal PJ, Gaw SL |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2024 May 13. Date of Electronic Publication: 2024 May 13. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Background: Fetal growth restriction (FGR) is associated with perinatal death and other adverse birth outcomes, as well as long term complications including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthood. FGR has been associated with placental epigenetic reprogramming, which may mediate these long term outcomes. Placental malaria (PM) is the leading cause of FGR globally, but the impact on placental epigenetics is unknown. We hypothesized that methylomic profiling of placentas from non-malarial and malarial FGR would reveal common and distinct mechanistic pathways associated with FGR. Results: We used a methylation array to compare the CpG profiles between FGR from a cohort with no malaria exposure and a cohort of pregnancies complicated by both PM and FGR. Non-malarial FGR was associated with 65 differentially methylated CpGs, whereas PM-FGR was associated with 133 DMCs, compared to their corresponding controls. One DMC (cg16389901) was commonly hypomethylated in both groups, corresponding to the promoter region of BMP4 . Comparison of FGR vs. PM-FGR identified 522 DMCs between these two groups, which was not attributable to geographic location or different cellular compositions of these two groups. Conclusion: Placentas from pregnancies with PM-associated FGR showed distinct methylation profiles as compared to non-malarial FGR, suggesting novel epigenetic reprogramming in response to malaria. There may be distinct long-term health outcomes in FGR pregnancies also complicated by PM. |
| معلومات مُعتمدة: | K08 AI141728 United States AI NIAID NIH HHS; L30 HD093159 United States HD NICHD NIH HHS; P01 HD059454 United States HD NICHD NIH HHS |
| تواريخ الأحداث: | Date Created: 20240527 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| مُعرف محوري في PubMed: | PMC11118523 |
| DOI: | 10.1101/2024.05.09.593431 |
| PMID: | 38798500 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2692-8205 |
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| DOI: | 10.1101/2024.05.09.593431 |