دورية أكاديمية
Frequent Disengagement and Subsequent Mortality Among People With HIV and Hepatitis C in Canada: A Prospective Cohort Study.
| العنوان: | Frequent Disengagement and Subsequent Mortality Among People With HIV and Hepatitis C in Canada: A Prospective Cohort Study. |
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| المؤلفون: | Saeed S; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada., Thomas T; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada., Dinh DA; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada., Moodie E; School of Population and Global Health, McGill University, Montreal, Quebec, Canada., Cox J; School of Population and Global Health, McGill University, Montreal, Quebec, Canada.; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Cooper C; Department of Medicine, University of Calgary, Calgary, Alberta, Canada., Gill J; Department of Medicine, Centre de recherche du Centre hospitalier de l'Université Montréal, Montreal, Quebec, Canada., Martel-Laferriere V; Department of Medicine, Centre de recherche du Centre hospitalier de l'Université Montréal, Montreal, Quebec, Canada., Panagiotoglou D; School of Population and Global Health, McGill University, Montreal, Quebec, Canada., Walmsley S; Department of Medicine, University Health Network, Toronto, Ontario, Canada., Wong A; Department of Medicine, Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada., Klein MB; Department of Medicine, Division of Infectious Diseases/Chronic Viral Illness Service, McGill University Health Center, Quebec, Canada.; Canadian HIV Trials Network, Vancouver, British Columbia, Canada. |
| المصدر: | Open forum infectious diseases [Open Forum Infect Dis] 2024 Apr 25; Vol. 11 (5), pp. ofae239. Date of Electronic Publication: 2024 Apr 25 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| مستخلص: | Background: The cascade of care, commonly used to assess HIV and hepatitis C (HCV) health service delivery, has limitations in capturing the complexity of individuals' engagement patterns. This study examines the dynamic nature of engagement and mortality trajectories among people with HIV and HCV. Methods: We used data from the Canadian HIV-HCV Co-Infection Cohort, which prospectively follows 2098 participants from 18 centers biannually. Markov multistate models were used to evaluate sociodemographic and clinical factors associated with transitioning between the following states: (1) lost-to-follow-up (LTFU), defined as no visit for 18 months; (2) reengaged (reentry into cohort after being LTFU); (3) withdrawn from the study (ie, moved); (4) death; otherwise remained (5) engaged-in-care. Results: A total of 1809 participants met the eligibility criteria and contributed 12 591 person-years from 2003 to 2022. LTFU was common, with 46% experiencing at least 1 episode, of whom only 57% reengaged. One in 5 (n = 383) participants died during the study. Participants who transitioned to LTFU were twice as likely to die as those who were consistently engaged. Factors associated with transitioning to LTFU included detectable HCV RNA (adjusted hazards ratio [aHR], 1.37; 95% confidence interval [CI], 1.13-1.67), evidence of HCV treatment but no sustained virologic response result (aHR, 1.99; 95% CI, 1.56-2.53), and recent incarceration (aHR, 1.94; 95% CI, 1.58-2.40). Being Indigenous was a significant predictor of death across all engagement trajectories. Interpretation: Disengagement from clinical care was common and resulted in higher death rates. People LTFU were more likely to require HCV treatment highlighting a priority population for elimination strategies. Competing Interests: Potential conflicts of interest. The authors declare the following financial interests: S. S. reports receiving honorariums for participation in ad hoc advisory boards for Novo Nordisk. M. B. K. reports grants for investigator-initiated studies from ViiV Healthcare, AbbVie, and Gilead; and consulting fees from ViiV Healthcare, Merck, AbbVie, and Gilead. J. G. reports receiving honorariums for participation in ad hoc advisory boards for ViiV Gilead and Merck. A. W. reports research grants from ViiV HealthCare, AbbVie, and Gilead Sciences and consulting fees from ViiV Healthcare, AbbVie, Merck, and Gilead Sciences. C. C. reports speaker fees, advisor fees and program support from Gilead Sciences, AbbVie, and ViiV Healthcare. J. C. reports grants for investigator-initiated studies from ViiV Healthcare and Gilead and consulting fees from ViiV Healthcare and Gilead. V. M. L. reports research grant from Merck and Gilead and consulting fee from AbbVie. S. W. reports grants for investigator-initiated studies from ViiV Healthcare, Merck, and Gilead and consulting fees and speaking at CME events for ViiV Healthcare, Merck, Gilead and Jannsen. All other authors report no potential conflicts. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| References: | J Acquir Immune Defic Syndr. 2017 Nov 1;76(3):303-310. (PMID: 28700406) Lancet Infect Dis. 2016 Jul;16(7):797-808. (PMID: 26922272) Lifetime Data Anal. 1999 Sep;5(3):239-64. (PMID: 10518372) J Int AIDS Soc. 2015 Nov 30;18:20634. (PMID: 26626715) BMC Gastroenterol. 2023 Feb 13;23(1):40. (PMID: 36782112) Lancet. 2017 Mar 4;389(10072):978-982. (PMID: 28271848) Curr HIV/AIDS Rep. 2021 Aug;18(4):299-308. (PMID: 33948789) J Int AIDS Soc. 2018 Nov;21(11):e25197. (PMID: 30460791) Int J Environ Res Public Health. 2020 Nov 11;17(22):. (PMID: 33187304) AIDS Behav. 2019 Apr;23(4):984-1003. (PMID: 30600452) Clin Infect Dis. 2020 Jul 11;71(2):363-371. (PMID: 31504327) Epidemiology. 2011 Jul;22(4):516-23. (PMID: 21522013) BMJ. 2023 Aug 2;382:e074001. (PMID: 37532284) AIDS. 2019 May 1;33(6):1013-1022. (PMID: 30946155) Can Commun Dis Rep. 2021 Dec 09;47(12):561-570. (PMID: 35692566) PLoS Med. 2021 May 24;18(5):e1003651. (PMID: 34029346) J Acquir Immune Defic Syndr. 2015 Jul 1;69(3):341-7. (PMID: 25835604) J Int AIDS Soc. 2017 Nov;20(3):. (PMID: 29116684) Int J Epidemiol. 2010 Oct;39(5):1162-9. (PMID: 19786463) CMAJ Open. 2019 Apr 12;7(2):E236-E245. (PMID: 30979728) Clin Liver Dis (Hoboken). 2020 Jul 21;16(1):8-11. (PMID: 32714516) J Viral Hepat. 2020 Dec;27(12):1270-1283. (PMID: 32964615) Clin Infect Dis. 2013 Oct;57(8):1164-71. (PMID: 23797289) CMAJ. 2023 Apr 11;195(14):E499-E512. (PMID: 37040993) Curr Opin HIV AIDS. 2011 Nov;6(6):478-82. (PMID: 22001892) AIDS. 2018 Sep 24;32(15):2217-2225. (PMID: 30005018) J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):531-539. (PMID: 27851713) HIV Med. 2017 Oct;18(9):685-689. (PMID: 28230318) Lancet HIV. 2018 Jun;5(6):e301-e308. (PMID: 29893243) |
| فهرسة مساهمة: | Keywords: HIV-Hepatitis C co-infection; cascade-of-care; disengagement; lost-to-follow-up; mortality |
| تواريخ الأحداث: | Date Created: 20240527 Latest Revision: 20240528 |
| رمز التحديث: | 20240528 |
| مُعرف محوري في PubMed: | PMC11127478 |
| DOI: | 10.1093/ofid/ofae239 |
| PMID: | 38798898 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2328-8957 |
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| DOI: | 10.1093/ofid/ofae239 |