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COVID-19 presenting as severe acute hepatitis in a pediatric patient with thalassemia minor: A case report.

التفاصيل البيبلوغرافية
العنوان: COVID-19 presenting as severe acute hepatitis in a pediatric patient with thalassemia minor: A case report.
المؤلفون: Jamalvi SA; Department of Internal Medicine Liaquat National Medical College Karachi Pakistan., Rauf SA; Department of Internal Medicine Liaquat National Medical College Karachi Pakistan., Sherali A; Department of Pediatrics Liaquat National Medical College Karachi Pakistan., Ali SK; Department of Internal Medicine Liaquat National Medical College Karachi Pakistan., Shah HH; Department of Internal Medicine Liaquat National Medical College Karachi Pakistan., Jamalvi F; Department of Internal Medicine Liaquat National Medical College Karachi Pakistan., Yogeeta F; Department of Internal Medicine Liaquat National Medical College Karachi Pakistan., Dave T; Bukovinian State Medical University Chernivtsi Ukraine.
المصدر: Clinical case reports [Clin Case Rep] 2024 May 24; Vol. 12 (6), pp. e8955. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101620385 Publication Model: eCollection Cited Medium: Print ISSN: 2050-0904 (Print) Linking ISSN: 20500904 NLM ISO Abbreviation: Clin Case Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Chichester, UK : John Wiley & Sons
مستخلص: Key Clinical Message: This case emphasizes the significance of COVID-19 in pediatric patients presenting with unusual hepatic manifestations, urging clinicians to broaden their diagnostic lens. The unexpected elevation of SARS-CoV-2 antibodies and the effective use of N-acetyl cysteine highlight the importance of adaptability in treatment strategies.
Abstract: This case report presents a unique manifestation of severe hepatic involvement in a 4-year-old girl with thalassemia minor and COVID-19. Despite the absence of prominent respiratory symptoms, the patient exhibited jaundice, elevated liver enzymes, and coagulopathy. Initial suspicion of viral hepatitis was replaced by the discovery of significantly elevated SARS-CoV-2 antibodies. A multidisciplinary approach, including gastroenterology consultation and an extensive workup, was pivotal in ruling out alternative etiologies. Unconventional use of N-acetyl cysteine contributed to clinical improvement, highlighting the need for adaptable treatment strategies. This case underscores the importance of heightened awareness in recognizing atypical presentations of COVID-19 in pediatric patients, especially those with underlying health conditions. Further exploration into nuanced manifestations and treatment approaches is warranted for comprehensive clinical management.
Competing Interests: None declared.
(© 2024 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: COVID‐19; SARS‐CoV‐2; coronavirus; hepatitis; thalassemia
تواريخ الأحداث: Date Created: 20240527 Latest Revision: 20240528
رمز التحديث: 20240528
مُعرف محوري في PubMed: PMC11126642
DOI: 10.1002/ccr3.8955
PMID: 38799536
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-0904
DOI:10.1002/ccr3.8955