دورية أكاديمية
Characteristics of Norovirus capsid protein-specific CD8 + T-Cell responses in previously infected individuals.
| العنوان: | Characteristics of Norovirus capsid protein-specific CD8 + T-Cell responses in previously infected individuals. |
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| المؤلفون: | He T; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Deng Y; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Zhang F; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Zhang J; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Zhu L; Department of Gastroenterology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Wang Q; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Ning J; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Wu H; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Yuan H; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Li B; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China., Wu C; Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. |
| المصدر: | Virulence [Virulence] 2024 Dec; Vol. 15 (1), pp. 2360133. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, Tex. : Landes Bioscience |
| مواضيع طبية MeSH: | CD8-Positive T-Lymphocytes*/immunology , Capsid Proteins*/immunology , Capsid Proteins*/genetics , Caliciviridae Infections*/immunology , Caliciviridae Infections*/virology , Norovirus*/immunology , Norovirus*/genetics , Epitopes, T-Lymphocyte*/immunology , Epitopes, T-Lymphocyte*/genetics , Gastroenteritis*/virology , Gastroenteritis*/immunology, Humans ; Adult ; Male ; Female ; Middle Aged ; Young Adult ; Child ; Adolescent ; Leukocytes, Mononuclear/immunology ; Immunodominant Epitopes/immunology ; Child, Preschool ; Aged |
| مستخلص: | Norovirus (NV) infection causes acute gastroenteritis in children and adults. Upon infection with NV, specific CD8 + T cells, which play an important role in anti-infective immunity, are activated in the host. Owing to the NV's wide genotypic variability, it is challenging to develop vaccines with cross-protective abilities against infection. To aid effective vaccine development, we examined specific CD8 + T-cell responses towards viral-structural protein (VP) epitopes, which enable binding to host susceptibility receptors. We isolated peripheral blood mononuclear cells from 196 participants to screen and identify predominant core peptides towards NV main and small envelope proteins using ex vivo and in vitro intracellular cytokine staining assays. Human leukocyte antigen (HLA) restriction characteristics were detected using next-generation sequencing. Three conservative immunodominant VP-derived CD8 + T-cell epitopes, VP2 |
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| فهرسة مساهمة: | Keywords: HLA-I-restricted characteristics; NV-specific CD8+ T-cells; Viral capsid protein; immunodominant epitopes |
| المشرفين على المادة: | 0 (Capsid Proteins) 0 (Epitopes, T-Lymphocyte) 0 (Immunodominant Epitopes) |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240530 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| مُعرف محوري في PubMed: | PMC11141469 |
| DOI: | 10.1080/21505594.2024.2360133 |
| PMID: | 38803081 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2150-5608 |
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| DOI: | 10.1080/21505594.2024.2360133 |