دورية أكاديمية
Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.
| العنوان: | Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. |
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| المؤلفون: | Brennan AM; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA., Coen PM; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA., Mau T; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA., Hetherington-Rauth M; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA., Toledo FGS; Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kershaw EE; Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Cawthon PM; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA., Kramer PA; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Ramos SV; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Cummings SR; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA., Forman DE; Divisions of Geriatrics and Cardiology, Department of Medicine, University of Pittsburgh, Geriatric Research Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA., Yeo RX; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA., Distefano G; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA., Miljkovic I; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Justice JN; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Molina AJA; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Division of Geriatrics, Gerontology, and Palliative Care, Department of Medicine, University of California, San Diego School of Medicine, San Diego, California, USA., Jurczak MJ; Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Sparks LM; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA., Kritchevsky SB; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Goodpaster BH; Translational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA. |
| المصدر: | Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Jun; Vol. 32 (6), pp. 1125-1135. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Malden, MA : John Wiley & Sons Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006- |
| مواضيع طبية MeSH: | Energy Metabolism*/physiology , Muscle, Skeletal*/metabolism , Body Mass Index*, Humans ; Female ; Aged ; Male ; Cross-Sectional Studies ; Oxidative Phosphorylation ; Magnetic Resonance Imaging ; Adipose Tissue/metabolism ; Body Fat Distribution ; Mitochondria, Muscle/metabolism ; Intra-Abdominal Fat/metabolism ; Aged, 80 and over |
| مستخلص: | Objective: The aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults. Methods: Cross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized in vivo ( 31 P-magnetic resonance spectroscopy; ATP Results: Independent of BMI, total abdominal AT (standardized [Std.] β = -0.21; R 2 = 0.09) and visceral AT (Std. β = -0.16; R 2 = 0.09) were associated with ATP Conclusions: Skeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and in vivo mitochondrial bioenergetics are attenuated by PA. (© 2024 The Obesity Society.) |
| التعليقات: | Update of: medRxiv. 2023 Nov 10:2023.11.10.23298359. doi: 10.1101/2023.11.10.23298359. (PMID: 37986822) |
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| معلومات مُعتمدة: | P30 AG024827 United States AG NIA NIH HHS; R01 AG058883 United States AG NIA NIH HHS; R01 AG061805 United States AG NIA NIH HHS; U19 AG065188 United States AG NIA NIH HHS; R01 AG060499 United States AG NIA NIH HHS; I21 RX004409 United States RX RRD VA; R01AG066474 United States AG NIA NIH HHS; R01 AG073633 United States AG NIA NIH HHS; U01 AG060897 United States AG NIA NIH HHS; K01 AG059837 United States AG NIA NIH HHS; P30 AG021332 United States AG NIA NIH HHS; R01 AG054523 United States AG NIA NIH HHS; R01 AG059416 United States AG NIA NIH HHS; R01 AG066474 United States AG NIA NIH HHS; R01 AG072734 United States AG NIA NIH HHS; P30 AG068635 United States AG NIA NIH HHS; R01AG059416 United States AG NIA NIH HHS; I01 HX003518 United States HX HSRD VA; UL1 TR001420 United States TR NCATS NIH HHS; P30AG024827 United States AG NIA NIH HHS; UL1TR001420 United States TR NCATS NIH HHS; P30AG021332 United States AG NIA NIH HHS; United Kingdom WT_ Wellcome Trust; R01 AG077179 United States AG NIA NIH HHS |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240528 Latest Revision: 20240806 |
| رمز التحديث: | 20240807 |
| مُعرف محوري في PubMed: | PMC11139412 |
| DOI: | 10.1002/oby.24008 |
| PMID: | 38803308 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1930-739X |
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| DOI: | 10.1002/oby.24008 |