دورية أكاديمية
أعرض في EDS

Varicella zoster virus-induced autophagy in human neuronal and hematopoietic cells exerts antiviral activity.

التفاصيل البيبلوغرافية
العنوان: Varicella zoster virus-induced autophagy in human neuronal and hematopoietic cells exerts antiviral activity.
المؤلفون: Heinz JL; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Hinke DM; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Maimaitili M; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Wang J; Institute of Virology, Hannover Medical School, Hannover, Germany., Sabli IKD; Dept of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK.; Centre for Paediatrics and Child Health, Imperial College London, London, UK., Thomsen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Farahani E; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Ren F; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Hu L; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Zillinger T; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, Bonn, Germany., Grahn A; Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., von Hofsten J; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Ophthalmology, Halland Hospital Halmstad, Halmstad, Sweden., Verjans GMGM; Department of Viroscience, HerpeslabNL, Erasmus University MC, Rotterdam, The Netherlands., Paludan SR; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Viejo-Borbolla A; Institute of Virology, Hannover Medical School, Hannover, Germany.; Cluster of Excellence-Resolving Infection Susceptibility (RESIST, EXC 2155), Hannover Medical School, Hannover, Germany., Sancho-Shimizu V; Dept of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK.; Centre for Paediatrics and Child Health, Imperial College London, London, UK., Mogensen TH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
المصدر: Journal of medical virology [J Med Virol] 2024 Jun; Vol. 96 (6), pp. e29690.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: Autophagy* , Herpesvirus 3, Human*/physiology , Herpesvirus 3, Human*/pathogenicity , Neurons*/virology, Humans ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy-Related Protein-1 Homolog/genetics ; Virus Replication ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Varicella Zoster Virus Infection/virology ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Cell Line ; Intracellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Host-Pathogen Interactions
مستخلص: Autophagy is a degradational pathway with pivotal roles in cellular homeostasis and survival, including protection of neurons in the central nervous system (CNS). The significance of autophagy as antiviral defense mechanism is recognized and some viruses hijack and modulate this process to their advantage in certain cell types. Here, we present data demonstrating that the human neurotropic herpesvirus varicella zoster virus (VZV) induces autophagy in human SH-SY5Y neuronal cells, in which the pathway exerts antiviral activity. Productively VZV-infected SH-SY5Y cells showed increased LC3-I-LC3-II conversion as well as co-localization of the viral glycoprotein E and the autophagy receptor p62. The activation of autophagy was dependent on a functional viral genome. Interestingly, inducers of autophagy reduced viral transcription, whereas inhibition of autophagy increased viral transcript expression. Finally, the genotype of patients with severe ocular and brain VZV infection were analyzed to identify potential autophagy-associated inborn errors of immunity. Two patients expressing genetic variants in the autophagy genes ULK1 and MAP1LC3B2, respectively, were identified. Notably, cells of both patients showed reduced autophagy, alongside enhanced viral replication and death of VZV-infected cells. In conclusion, these results demonstrate a neuro-protective role for autophagy in the context of VZV infection and suggest that failure to mount an autophagy response is a potential predisposing factor for development of severe VZV disease.
(© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
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معلومات مُعتمدة: 4004-00047B Danmarks Frie Forskningsfond; NNF21OC0067157 Novo Nordisk research foundation; NNF20OC0063436 Novo Nordisk research foundation; DNRF164 Danmarks Grundforskningsfond; R268-3927 Lundbeck Foundation; 39087480 Deutsche forschungsgemeinschaft
فهرسة مساهمة: Keywords: CNS infection; acute retinal necrosis; autophagy; innate immunity; varicella zoster virus
المشرفين على المادة: EC 2.7.11.1 (Autophagy-Related Protein-1 Homolog)
EC 2.7.11.1 (ULK1 protein, human)
0 (Microtubule-Associated Proteins)
0 (Viral Envelope Proteins)
0 (MAP1LC3B protein, human)
0 (glycoprotein E, varicella-zoster virus)
0 (Intracellular Signaling Peptides and Proteins)
تواريخ الأحداث: Date Created: 20240528 Date Completed: 20240528 Latest Revision: 20240528
رمز التحديث: 20240528
DOI: 10.1002/jmv.29690
PMID: 38804180
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9071
DOI:10.1002/jmv.29690