دورية أكاديمية
Eukaryotic genomic data uncover an extensive host range of mirusviruses.
| العنوان: | Eukaryotic genomic data uncover an extensive host range of mirusviruses. |
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| المؤلفون: | Zhao H; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan., Meng L; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan., Hikida H; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan., Ogata H; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. Electronic address: ogata@kuicr.kyoto-u.ac.jp. |
| المصدر: | Current biology : CB [Curr Biol] 2024 Jun 17; Vol. 34 (12), pp. 2633-2643.e3. Date of Electronic Publication: 2024 May 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
| مواضيع طبية MeSH: | Phylogeny* , Host Specificity*/genetics , Eukaryota*/genetics , Eukaryota*/virology, Genome, Viral ; DNA Viruses/genetics ; Metagenomics |
| مستخلص: | A recent marine metagenomic study has revealed the existence of a novel group of viruses designated mirusviruses, which are proposed to form an evolutionary link between two realms of double-stranded DNA viruses, Varidnaviria and Duplodnaviria. Metagenomic data suggest that mirusviruses infect microeukaryotes in the photic layer of the ocean, but their host range remains largely unknown. In this study, we investigated the presence of mirusvirus marker genes in 1,901 publicly available eukaryotic genome assemblies, mainly derived from unicellular eukaryotes, to identify potential hosts of mirusviruses. Mirusvirus marker sequences were identified in 915 assemblies spanning 227 genera across eight supergroups of eukaryotes. The habitats of the putative mirusvirus hosts included not only marine but also other diverse environments. Among the major capsid protein (MCP) signals in the genome assemblies, we identified 85 sequences that showed high sequence and structural similarities to reference mirusvirus MCPs. A phylogenetic analysis of these sequences revealed their distant evolutionary relationships with the seven previously reported mirusvirus clades. Most of the scaffolds with these MCP sequences encoded multiple mirusvirus homologs, suggesting that mirusviral infection contributes to the alteration of the host genome. We also identified three circular mirusviral genomes within the genomic data of the oil-producing thraustochytrid Schizochytrium sp. and the endolithic green alga Ostreobium quekettii. Overall, mirusviruses probably infect a wide spectrum of eukaryotes and are more diverse than previously reported. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| التعليقات: | Update of: bioRxiv. 2024 Jan 25:2024.01.18.576163. doi: 10.1101/2024.01.18.576163. (PMID: 38293090) |
| فهرسة مساهمة: | Keywords: endogenous virus; major capsid protein; mirusvirus; protist; virus-host relationship |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240618 Latest Revision: 20240619 |
| رمز التحديث: | 20240620 |
| DOI: | 10.1016/j.cub.2024.04.085 |
| PMID: | 38806056 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1879-0445 |
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| DOI: | 10.1016/j.cub.2024.04.085 |