دورية أكاديمية
Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes.
| العنوان: | Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. |
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| المؤلفون: | Aneni EC; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8017, USA. ehianeni@outlook.com., Sinusas AJ; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8017, USA.; Department of Bioengineering, Yale University, 17 Hillhouse Avenue, New Haven, CT, 06520-8292, USA., Emokpae MC; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8017, USA., Thorn SL; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8017, USA., Yaggi HK; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06520-8057, USA., Miller EJ; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8017, USA. |
| المصدر: | Current cardiology reports [Curr Cardiol Rep] 2024 Jul; Vol. 26 (7), pp. 723-734. Date of Electronic Publication: 2024 May 28. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Current Science Country of Publication: United States NLM ID: 100888969 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-3170 (Electronic) Linking ISSN: 15233782 NLM ISO Abbreviation: Curr Cardiol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Current Science, c1999- |
| مواضيع طبية MeSH: | Sleep Apnea, Obstructive*/therapy , Sleep Apnea, Obstructive*/physiopathology , Sleep Apnea, Obstructive*/complications , Continuous Positive Airway Pressure* , Coronary Circulation*/physiology , Microcirculation*/physiology , Cardiovascular Diseases*/physiopathology , Cardiovascular Diseases*/etiology, Humans ; Fractional Flow Reserve, Myocardial/physiology |
| مستخلص: | Purpose of Review: Recent studies have demonstrated an association between obstructive sleep apnea (OSA) and abnormal myocardial blood flow (MBF), myocardial flow reserve (MFR), and coronary microvascular dysfunction (CMD). Here, we review the evidence and describe the potential underlying mechanisms linking OSA to abnormal MBF. Examining relevant studies, we assess the impact of OSA-specific therapy, such as continuous positive airway pressure (CPAP), on MBF. Recent Findings: Recent studies suggest an association between moderate to severe OSA and abnormal MBF/MFR. OSA promotes functional and structural abnormalities of the coronary microcirculation. OSA also promotes the uncoupling of MBF to cardiac work. In a handful of studies with small sample sizes, CPAP therapy improved MBF/MFR. Moderate to severe OSA is associated with abnormal MFR, suggesting an association with CMD. Evidence suggests that CPAP therapy improves MBF. Future studies must determine the clinical impact of improved MBF with CPAP. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| فهرسة مساهمة: | Keywords: Cardiac PET; Continuous positive airway pressure therapy; Coronary microvascular dysfunction; Myocardial blood flow; Myocardial flow reserve; Obstructive sleep apnea |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240710 Latest Revision: 20240710 |
| رمز التحديث: | 20240710 |
| DOI: | 10.1007/s11886-024-02072-z |
| PMID: | 38806976 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1534-3170 |
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| DOI: | 10.1007/s11886-024-02072-z |