دورية أكاديمية
Bound Polyphenols of Oat Bran Released by Gut Microbiota Mitigate High Fat Diet-Induced Oxidative Stress and Strengthen the Gut Barrier via the Colonic ROS/Akt/Nrf2 Pathway.
| العنوان: | Bound Polyphenols of Oat Bran Released by Gut Microbiota Mitigate High Fat Diet-Induced Oxidative Stress and Strengthen the Gut Barrier via the Colonic ROS/Akt/Nrf2 Pathway. |
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| المؤلفون: | Zhang Y; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China., Bai B; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China., Huang K; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China., Li S; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China., Cao H; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China., Guan X; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jun 12; Vol. 72 (23), pp. 13099-13110. Date of Electronic Publication: 2024 May 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*/drug effects , Polyphenols*/pharmacology , Polyphenols*/chemistry , Polyphenols*/administration & dosage , Polyphenols*/metabolism , Avena*/chemistry , Avena*/metabolism , Oxidative Stress*/drug effects , Dietary Fiber*/metabolism , Dietary Fiber*/pharmacology , Diet, High-Fat*/adverse effects , Mice, Inbred C57BL* , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Colon*/metabolism , Colon*/microbiology , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Reactive Oxygen Species*/metabolism, Animals ; Mice ; Male ; Humans ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/metabolism ; Bacteria/drug effects |
| مستخلص: | Whole-grain foods are rich in bound polyphenols (BPs) whose health benefits were largely underestimated compared with free polyphenols. We first found that DFBP (dietary fiber with BPs from oat bran) exhibited stronger colonic antioxidant activities than DF. 16S rRNA sequencing showed that DFBP selectively changed gut microbial composition, which reciprocally released BPs from DFBP. Released polyphenols from DFBP reduced excessive colonic ROS and exhibited colonic antioxidant activities via the ROS/Akt/Nrf2 pathway revealed by transcriptome and western blot analysis. Colonic antioxidant activities of DFBP mediated by gut microbiota were next proven by treating mice with broad-spectrum antibiotics. Next, Clostridium butyricum , as a distinguished bacterium after DFBP intervention, improved colonic antioxidant capacities synergistically with DFBP in HFD-fed mice. This was explained by the upregulated mRNA expression of esterase, and cellulase of Clostridium butyricum participated in releasing BPs. Our results would provide a solid basis for explaining the health benefits of whole grains. |
| فهرسة مساهمة: | Keywords: bound polyphenols; gut microbiota; high fat diet; oat bran; whole grain |
| المشرفين على المادة: | 0 (Polyphenols) 0 (Dietary Fiber) 0 (NF-E2-Related Factor 2) EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240612 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1021/acs.jafc.4c01666 |
| PMID: | 38807079 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.4c01666 |