دورية أكاديمية
أعرض في EDS

Effect of cevimeline and different concentration of gum arabic on parotid salivary gland function in methotrexate-induced xerostomia: a comparative study.

التفاصيل البيبلوغرافية
العنوان: Effect of cevimeline and different concentration of gum arabic on parotid salivary gland function in methotrexate-induced xerostomia: a comparative study.
المؤلفون: Aboulfotoh MM; Oral Biology Department, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Gamasa, Egypt. Mahmoud.abouelfotouh@deltauniv.edu.eg.
المصدر: BMC oral health [BMC Oral Health] 2024 May 28; Vol. 24 (1), pp. 624. Date of Electronic Publication: 2024 May 28.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Xerostomia*/chemically induced , Parotid Gland*/drug effects , Parotid Gland*/pathology , Ki-67 Antigen*/analysis , Ki-67 Antigen*/metabolism , Methotrexate* , Gum Arabic*/pharmacology , Thiophenes*/pharmacology, Animals ; Rats ; Caspase 3/metabolism ; Male ; Rats, Wistar ; Quinuclidines
مستخلص: Objective: This study assessed the effect of cevimeline and different concentrations of gum arabic on the parotid gland of rats being given xerostomia-inducing methotrexate.
Methods: One hundred twenty-five rats were divided into five equal groups of twenty-five each. The rats in Group I received basic diets, while those in Groups II, III, IV, and V received 20 mg/kg MTX as a single intraperitoneal dose on day one. Group III received 10 mg/kg CVM dissolved in saline orally and daily, and the other two groups received a 10% W/V aqueous suspension of GA. Therefore, Group IV received 2 ml/kg suspension orally and daily, while Group V received 3 ml/kg suspension orally and daily. After 9 days, the parotid glands were dissected carefully and prepared for hematoxylin and eosin (H&E) staining as a routine histological stain and caspase-3 and Ki67 immunohistochemical staining. Quantitative data from α-Caspase-3 staining and Ki67 staining were statistically analysed using one-way ANOVA followed by Tukey's multiple comparisons post hoc test.
Results: Regarding caspase-3 and Ki67 immunohistochemical staining, one-way ANOVA revealed a significant difference among the five groups. For Caspase-3, the highest mean value was for group II (54.21 ± 6.90), and the lowest mean value was for group I (15.75 ± 3.67). The other three groups had mean values of 31.09 ± 5.90, 30.76 ± 5.82, and 20.65 ± 3.47 for groups III, IV, and V, respectively. For Ki67, the highest mean value was for group I (61.70 ± 6.58), and the lowest value was for group II (18.14a ± 5.16). The other three groups had mean values of 34.4 ± 9.27, 48.03 ± 8.40, and 50.63 ± 8.27 for groups III, IV, and V, respectively.
Conclusion: GA, rather than the normally used drug CVM, had a desirable effect on the salivary glands of patients with xerostomia.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Cevimeline; Gum arabic; Immunohistochemical staining; Methotrexate; Parotid
المشرفين على المادة: K9V0CDQ56E (cevimeline)
0 (Ki-67 Antigen)
YL5FZ2Y5U1 (Methotrexate)
9000-01-5 (Gum Arabic)
0 (Thiophenes)
EC 3.4.22.- (Caspase 3)
0 (Quinuclidines)
تواريخ الأحداث: Date Created: 20240528 Date Completed: 20240529 Latest Revision: 20240531
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC11134700
DOI: 10.1186/s12903-024-04374-8
PMID: 38807094
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6831
DOI:10.1186/s12903-024-04374-8