دورية أكاديمية
Synthesis of All-Peptide-Based Rotaxane from a Proline-Containing Cyclic Peptide.
| العنوان: | Synthesis of All-Peptide-Based Rotaxane from a Proline-Containing Cyclic Peptide. |
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| المؤلفون: | Kurita T; Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan., Higashi M; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan., Gimenez-Dejoz J; Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.; Life Sciences Department, Barcelona Supercomputing Center, Jordi Girona 31, 08034 Barcelona, Spain., Fujita S; Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan., Uji H; Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan., Sato H; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.; Fukui Institute for Fundamental Chemistry, Kyoto University, Takano-Nishibiraki-cho 34-4, Sakyou-ku, Kyoto 606-8103, Japan., Numata K; Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.; Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.; Institute for Advanced Biosciences, Keio University, Nipponkoku 403-1, Daihouji, Tsuruoka, Yamagata 997-0017, Japan. |
| المصدر: | Biomacromolecules [Biomacromolecules] 2024 Jun 10; Vol. 25 (6), pp. 3661-3670. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c2000- |
| مواضيع طبية MeSH: | Rotaxanes*/chemistry , Rotaxanes*/chemical synthesis , Proline*/chemistry , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis, Molecular Dynamics Simulation |
| مستخلص: | Rotaxane cross-linkers enhance the toughness of the resulting rotaxane cross-linked polymers through a stress dispersion effect, which is attributed to the mobility of the interlocked structure. To date, the compositional diversity of rotaxane cross-linkers has been limited, and the poor compatibility of these cross-linkers with peptides and proteins has made their use in such materials challenging. The synthesis of a rotaxane composed of peptides may result in a biodegradable cross-linker that is compatible with peptides and proteins, allowing the fortification of polypeptides and proteins and ultimately leading to the development of innovative materials that possess excellent mechanical properties and biodegradability. However, the chemical synthesis of all-peptide-based rotaxanes has remained elusive because of the absence of strong binding motifs in peptides, which prevents an axial peptide from penetrating a cyclic peptide. Here, we synthesized all-peptide-based rotaxanes using an active template method for proline-containing cyclic peptides. The results of molecular dynamics simulations suggested that cyclic peptides with an expansive inner cavity and carbonyl oxygens oriented toward the center are favorable for rotaxane synthesis. This rotaxane synthesis method is expected to accelerate the synthesis of peptides and proteins with mechanically interlocked structures, potentially leading to the development of peptide- and protein-based materials with unprecedented functionalities. |
| المشرفين على المادة: | 0 (Rotaxanes) 9DLQ4CIU6V (Proline) 0 (Peptides, Cyclic) |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240610 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1021/acs.biomac.4c00257 |
| PMID: | 38807574 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1526-4602 |
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| DOI: | 10.1021/acs.biomac.4c00257 |