دورية أكاديمية
Melanopsin-mediated amplification of cone signals in the human visual cortex.
| العنوان: | Melanopsin-mediated amplification of cone signals in the human visual cortex. |
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| المؤلفون: | Adhikari P; Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia., Uprety S; Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia., Feigl B; Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia.; School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia.; Queensland Eye Institute, Brisbane, Queensland 4101, Australia., Zele AJ; Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia. |
| المصدر: | Proceedings. Biological sciences [Proc Biol Sci] 2024 May; Vol. 291 (2023), pp. 20232708. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of London Country of Publication: England NLM ID: 101245157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2954 (Electronic) Linking ISSN: 09628452 NLM ISO Abbreviation: Proc Biol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Royal Society of London, c1990- |
| مواضيع طبية MeSH: | Rod Opsins*/metabolism , Retinal Cone Photoreceptor Cells*/physiology , Retinal Cone Photoreceptor Cells*/metabolism , Visual Cortex*/physiology, Humans ; Adult ; Electroretinography ; Evoked Potentials, Visual ; Female ; Male ; Young Adult ; Photic Stimulation |
| مستخلص: | The ambient daylight variation is coded by melanopsin photoreceptors and their luxotonic activity increases towards midday when colour temperatures are cooler, and irradiances are higher. Although melanopsin and cone photoresponses can be mediated via separate pathways, the connectivity of melanopsin cells across all levels of the retina enables them to modify cone signals. The downstream effects of melanopsin-cone interactions on human vision are however, incompletely understood. Here, we determined how the change in daytime melanopsin activation affects the human cone pathway signals in the visual cortex. A 5-primary silent-substitution method was developed to evaluate the dependence of cone-mediated signals on melanopsin activation by spectrally tuning the lights and stabilizing the rhodopsin activation under a constant cone photometric luminance. The retinal (white noise electroretinogram) and cortical responses (visual evoked potential) were simultaneously recorded with the photoreceptor-directed lights in 10 observers. By increasing the melanopsin activation, a reverse response pattern was observed with cone signals being supressed in the retina by 27% ( p = 0.03) and subsequently amplified by 16% ( p = 0.01) as they reach the cortex. We infer that melanopsin activity can amplify cone signals at sites distal to retinal bipolar cells to cause a decrease in the psychophysical Weber fraction for cone vision. |
| فهرسة مساهمة: | Keywords: cones; electroretinogram; melanopsin; vision; visual evoked potentials |
| المشرفين على المادة: | 0 (Rod Opsins) 0 (melanopsin) |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240529 Latest Revision: 20240529 |
| رمز التحديث: | 20240529 |
| DOI: | 10.1098/rspb.2023.2708 |
| PMID: | 38808443 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1471-2954 |
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| DOI: | 10.1098/rspb.2023.2708 |