دورية أكاديمية
أعرض في EDS

Functional Heterogeneity of Umbilical Cord Blood Monocyte-Derived Dendritic Cells.

التفاصيل البيبلوغرافية
العنوان: Functional Heterogeneity of Umbilical Cord Blood Monocyte-Derived Dendritic Cells.
المؤلفون: Schweiger P; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Hamann L; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Strobel J; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Weisbach V; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Wandersee A; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Christ J; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Kehl S; Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany., Weidenthaler F; Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany., Antoniadis S; Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany., Hackstein H; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany., Cunningham S; Department of Transfusion Medicine and Haemostaseology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany.
المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Jul 15; Vol. 213 (2), pp. 115-124.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Bethesda, MD : American Association of Immunologists
Original Publication: Baltimore : Williams & Wilkins, c1950-
مواضيع طبية MeSH: Fetal Blood*/cytology , Fetal Blood*/immunology , Dendritic Cells*/immunology , Monocytes*/immunology, Humans ; Cell Differentiation/immunology ; Coculture Techniques ; Cells, Cultured ; Cytokines/metabolism ; Cytokines/immunology ; Lymphocyte Activation/immunology ; Adult ; Cell Proliferation
مستخلص: Human umbilical cord blood (UCB) represents a unique resource for hematopoietic stem cell transplantation for children and patients lacking suitable donors. UCB harbors a diverse set of leukocytes such as professional APCs, including monocytes, that could act as a novel source for cellular therapies. However, the immunological properties of UCB monocytes and monocyte-derived dendritic cells (MoDCs) are not fully characterized. In this study, we characterized the phenotype and functions of UCB-MoDCs to gauge their potential for future applications. UCB exhibited higher frequencies of platelets and lymphocytes as well as lower frequencies of neutrophils in comparison with adult whole blood. Leukocyte subset evaluation revealed significantly lower frequencies of granulocytes, NK cells, and CD14+CD16- monocytes. Surface marker evaluation revealed significantly lower rates of costimulatory molecules CD80 and CD83 while chemokine receptors CCR7 and CXCR4, as well as markers for Ag presentation, were similarly expressed. UCB-MoDCs were sensitive to TLR1-9 stimulation and presented quantitative differences in the release of proinflammatory cytokines. UCB-MoDCs presented functional CCR7-, CXCR4-, and CCR5-associated migratory behavior as well as adequate receptor- and micropinocytosis-mediated Ag uptake. When cocultured with allogeneic T lymphocytes, UCB-MoDCs induced weak CD4+ T lymphocyte proliferation, CD71 expression, and release of IFN-γ and IL-2. Taken together, UCB-MoDCs present potentially advantageous properties for future medical applications.
(Copyright © 2024 by The American Association of Immunologists, Inc.)
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المشرفين على المادة: 0 (Cytokines)
تواريخ الأحداث: Date Created: 20240529 Date Completed: 20240701 Latest Revision: 20240709
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC11215632
DOI: 10.4049/jimmunol.2400036
PMID: 38809115
قاعدة البيانات: MEDLINE
الوصف
تدمد:1550-6606
DOI:10.4049/jimmunol.2400036