دورية أكاديمية

Clinical Value of the Quantitative Flow Ratio to Predict Long-term Target Vessel Failure in Patients with In-stent Restenosis after Drug-coated Balloon Angioplasty.

التفاصيل البيبلوغرافية
العنوان: Clinical Value of the Quantitative Flow Ratio to Predict Long-term Target Vessel Failure in Patients with In-stent Restenosis after Drug-coated Balloon Angioplasty.
المؤلفون: Wu XQ; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China., Li LB; Department of Cardiology, The Second Hospital of Jilin University, Jilin, 130000, China., You W; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China., Wu ZM; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China., Zhao L; Department of Cardiology, The Second Hospital of Jilin University, Jilin, 130000, China., Wang ZH; Department of Cardiology, The Second Hospital of Jilin University, Jilin, 130000, China., Meng PN; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China., Liu B; Department of Cardiology, The Second Hospital of Jilin University, Jilin, 130000, China. liubin3333@vip.sina.com., Ye F; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. njsdxn2017@163.com.
المصدر: Current medical science [Curr Med Sci] 2024 Jun; Vol. 44 (3), pp. 561-567. Date of Electronic Publication: 2024 May 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Huazhong University of Science and Technology Country of Publication: China NLM ID: 101729993 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-899X (Electronic) Linking ISSN: 2523899X NLM ISO Abbreviation: Curr Med Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wuhan : Huazhong University of Science and Technology, [2018]-
مواضيع طبية MeSH: Coronary Restenosis*/etiology , Coronary Restenosis*/diagnostic imaging , Angioplasty, Balloon, Coronary*/methods , Angioplasty, Balloon, Coronary*/adverse effects, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Drug-Eluting Stents ; Follow-Up Studies ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/physiopathology ; Coronary Vessels/surgery
مستخلص: Objective: The study sought to investigate the clinical predictive value of quantitative flow ratio (QFR) for the long-term target vessel failure (TVF) outcome in patients with in-stent restenosis (ISR) by using drug-coated balloon (DCB) treatment after a long-term follow-up.
Methods: This was a retrospective study. A total of 186 patients who underwent DCB angioplasty for ISR in two hospitals from March 2014 to September 2019 were enrolled. The QFR of the entire target vessel was measured offline. The primary endpoint was TVF, including target vessel-cardiac death (TV-CD), target vessel-myocardial infarction (TV-MI), and clinically driven-target vessel revascularization (CD-TVR).
Results: The follow-up time was 3.09±1.53 years, and 50 patients had TVF. The QFR immediately after percutaneous coronary intervention (PCI) was significantly lower in the TVF group than in the no-TVF group. Multivariable Cox regression analysis indicated that the QFR immediately after PCI was an excellent predictor for TVF after the long-term follow-up [hazard ratio (HR): 5.15×10 -5 (6.13×10 -8 -0.043); P<0.01]. Receiver-operating characteristic (ROC) curve analysis demonstrated that the optimal cut-off value of the QFR immediately after PCI for predicting the long-term TVF was 0.925 (area under the curve: 0.886, 95% confidence interval: 0.834-0.938; sensitivity: 83.40%, specificity: 88.00; P<0.01). In addition, QFR≤0.925 post-PCI was strongly correlated with the TVF, including TV-MI and CD-TVR (P<0.01).
Conclusion: The QFR immediately after PCI showed a high predictive value of TVF after a long-term follow-up in ISR patients who underwent DCB angioplasty. A lower QFR immediately after PCI was associated with a worse TVF outcome.
(© 2024. Huazhong University of Science and Technology.)
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فهرسة مساهمة: Keywords: in-stent restenosis; percutaneous coronary intervention; quantitative flow ratio; target vessel failure
تواريخ الأحداث: Date Created: 20240529 Date Completed: 20240627 Latest Revision: 20240627
رمز التحديث: 20240628
DOI: 10.1007/s11596-024-2876-0
PMID: 38809380
قاعدة البيانات: MEDLINE
الوصف
تدمد:2523-899X
DOI:10.1007/s11596-024-2876-0