دورية أكاديمية
أعرض في EDS

Diaryl pyrrolone fluorescent probing strategy for Mirabegron determination through condensation with ninhydrin and phenylacetaldehyde: Application to dosage forms, human urine and plasma.

التفاصيل البيبلوغرافية
العنوان: Diaryl pyrrolone fluorescent probing strategy for Mirabegron determination through condensation with ninhydrin and phenylacetaldehyde: Application to dosage forms, human urine and plasma.
المؤلفون: Derayea SM; Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: sayed_derayea@yahoo.com., Ahmed AS; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt., Abdelshakour MA; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt., Oraby M; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt., Badr El-Din KM; Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
المصدر: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Oct 05; Vol. 318, pp. 124515. Date of Electronic Publication: 2024 May 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE
أسماء مطبوعة: Publication: : Amsterdam : Elsevier
Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994-
مواضيع طبية MeSH: Ninhydrin*/chemistry , Spectrometry, Fluorescence*/methods , Limit of Detection* , Acetanilides*/urine , Acetanilides*/blood , Acetanilides*/chemistry , Thiazoles*/chemistry , Thiazoles*/urine , Thiazoles*/blood, Humans ; Pyrroles/chemistry ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/chemical synthesis ; Tablets ; Acetaldehyde/analogs & derivatives
مستخلص: Mirabegron (MRB) is a β 3 -adrenoceptor agonist used for managing overactive bladder syndrome. A cost-effective, environmentally friendly, and highly sensitive spectrofluorimetric method was suggested to serve the purpose of quantifying MRB in its pure state, pharmaceutical tablets, spiked human plasma and urine, and testing content uniformity. In the present study, ninhydrin and phenylacetaldehyde react with the amino group moiety of MRB in Teorell-Stenhagen buffer (pH 7.5) to generate a strongly fluorescent diaryl pyrrolone compound that emits fluorescence at a wavelength of 477 nm upon excitation at 385 nm. The obtained calibration curve showed a linear relationship with a high correlation coefficient (r = 0.9997) in the concentration range of 0.25 to 5.0 µg mL -1 . Limits of detection (LOD) and quantitation (LOQ) were 0.082 and 0.248 µg mL -1 respectively. The procedure was verified in accordance with the ICH guidelines. The suggested approach could be utilized for the selective analysis of MRB in its pharmaceuticals, either containing a single drug or co-formulated with solifenacin succinate. The greenness of the suggested method was confirmed using different green analytical metrics.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Biological fluids; Fluorescence; Mirabegron; Ninhydrin; Pharmaceutical
المشرفين على المادة: HCL6S9K23A (Ninhydrin)
MVR3JL3B2V (mirabegron)
0 (Acetanilides)
0 (Thiazoles)
U8J5PLW9MR (phenylacetaldehyde)
0 (Pyrroles)
0 (Fluorescent Dyes)
0 (Tablets)
GO1N1ZPR3B (Acetaldehyde)
تواريخ الأحداث: Date Created: 20240529 Date Completed: 20240609 Latest Revision: 20240609
رمز التحديث: 20240610
DOI: 10.1016/j.saa.2024.124515
PMID: 38810435
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3557
DOI:10.1016/j.saa.2024.124515