دورية أكاديمية
Exposure to organophosphate esters among Inuit adults of Nunavik, Canada.
| العنوان: | Exposure to organophosphate esters among Inuit adults of Nunavik, Canada. |
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| المؤلفون: | Nero E; Department of Health and Society, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada., Caron-Beaudoin É; Department of Health and Society, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Ontario, Canada. Electronic address: elyse.caronbeaudoin@utoronto.ca., Aker A; Axe santé des Populations et Pratiques Optimales en santé, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada; Département de médecine sociale et Préventive, Université Laval, Québec, Québec, Canada., Gaudreau É; Centre de Toxicologie du Québec (CTQ), Institut national de santé publique du Québec (INSPQ), Québec, Canada., Ayotte P; Centre de Toxicologie du Québec (CTQ), Institut national de santé publique du Québec (INSPQ), Québec, Canada; Axe santé des Populations et Pratiques Optimales en santé, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada., Blanchette C; Axe santé des Populations et Pratiques Optimales en santé, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada., Lemire M; Axe santé des Populations et Pratiques Optimales en santé, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada; Institut de Biologie Intégrative et des systèmes (IBIS), Université Laval, Québec, Québec, Canada. |
| المصدر: | The Science of the total environment [Sci Total Environ] 2024 Aug 20; Vol. 939, pp. 173563. Date of Electronic Publication: 2024 May 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Inuit* , Organophosphates*/urine , Environmental Exposure*/statistics & numerical data , Environmental Exposure*/analysis , Flame Retardants*/analysis, Humans ; Adult ; Female ; Male ; Middle Aged ; Young Adult ; Quebec ; Adolescent ; Environmental Pollutants/urine ; Esters |
| مستخلص: | Halogenated organophosphate esters (OPEs) are increasingly used as flame retardants to replace polybrominated diphenyl ethers (PBDEs), which have been phased out due to their confirmed persistence, toxicity, and ability to undergo long range atmospheric transport. Non-halogenated OPEs are primarily used as plasticizers. While human exposure to PBDEs in the Canadian Arctic is well documented, it is not the case for OPEs. To assess the exposure to OPEs in Inuit living in Nunavik (northern Québec, Canada), we measured 16 metabolites of halogenated and non-halogenated OPEs in pooled urine samples from the last population health survey conducted in Nunavik, the Qanuilirpitaa? 2017 Inuit Health Survey (Q2017). Urine samples (n = 1266) were pooled into 30 pools by sex (female; male), age groups (16-19; 20-29; 30-39; 40-59; 60+ years old) and regions (Hudson Bay; Hudson Strait; Ungava Bay). Q2017 geometric means and 95 % confidence intervals were compared with data from the Canadian Health Measures Survey Cycle 6 (2018-2019) (CHMS). Halogenated OPEs were systematically detected and generally found at higher concentrations than non-halogenated OPEs in both Q2017 and CHMS. Furthermore, urinary levels of BCIPP and BDCIPP (halogenated) were lower in Q2017 compared to CHMS while concentrations of DPhP, DpCP and DoCP (non-halogenated) were similar between Q2017 and CHMS. Across the 16 metabolites measured in Q2017, BCIPHIPP (halogenated) had the highest levels (geometric mean: 1.40 μg/g creatinine). This metabolite was not measured in CHMS and should be included in future surveys. Overall, our results show that Inuit in Nunavik are exposed to lower or similar OPEs levels than the rest of the general Canadian population suggesting that the main current exposure to OPEs may be from consumer goods containing flame retardants and imported from the south rather than long-range atmospheric transport to the Arctic. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomonitoring; Flame retardants; Nunavik; Organophosphate esters; Plasticizers |
| المشرفين على المادة: | 0 (Organophosphates) 0 (Flame Retardants) 0 (Environmental Pollutants) 0 (Esters) |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240613 Latest Revision: 20240613 |
| رمز التحديث: | 20240614 |
| DOI: | 10.1016/j.scitotenv.2024.173563 |
| PMID: | 38810742 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
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| DOI: | 10.1016/j.scitotenv.2024.173563 |