دورية أكاديمية
Racial Disparities in Breast Cancer Genetic Testing May be Mitigated by Counseling.
| العنوان: | Racial Disparities in Breast Cancer Genetic Testing May be Mitigated by Counseling. |
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| المؤلفون: | Siegel JB; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA. siegelju@musc.edu., Bertolino M; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA., Mukherjee R; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA., Meeder K; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA., Hughes KS; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA., Abbott AM; Department of Surgery, Medical University of South Carolina, Charleston, SC, USA. |
| المصدر: | Annals of surgical oncology [Ann Surg Oncol] 2024 Aug; Vol. 31 (8), pp. 5197-5204. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994- |
| مواضيع طبية MeSH: | Breast Neoplasms*/genetics , Breast Neoplasms*/diagnosis , Genetic Counseling*/statistics & numerical data , Genetic Testing*/statistics & numerical data , Healthcare Disparities*, Adult ; Aged ; Female ; Humans ; Middle Aged ; Black or African American ; Follow-Up Studies ; Genetic Predisposition to Disease ; Health Services Accessibility/statistics & numerical data ; Prognosis ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; White People/statistics & numerical data ; White People/genetics ; White |
| مستخلص: | Background: Currently, racial disparities exist in access to genetic testing. Recent developments have helped narrow the gap in accessibility. The purpose of this study was to determine whether racial disparities in genetic consultation attendance and completion of genetic testing persist, and, if so, factors that contribute to under-utilization of these resources. Methods: A single-institution retrospective review of breast patients referred for genetic counseling between 2017 and 2019 was performed. Univariate and multivariate logistic regression evaluated factors associated with genetic counseling attendance and genetic testing. Results: A total of 596 patients were referred for genetic counseling: 433 (72.7%) white; 138 (23.2%) black; and 25 (4.2%) other or unknown. In multivariate analysis, black patients, patients without breast cancer family history, and patients without a current cancer diagnosis, classified as high risk, were significantly less likely to attend their genetics appointment (p = 0.010, p = 0.007, p = 0.005, respectively). Age, insurance type, distance from facility, and need for chemotherapy did not significantly impact consult completion rate. Of the patients who completed a genetic consult, 84.4% (n = 248) had genetic testing and 17.7% (n = 44) had a pathogenic variant. For patients who attended counseling, there were no significant factors that were predictive with receipt of genetic testing. Conclusions: In this study, there was a significant association between race and attending genetic counseling. Once counseled, most patients went on to receive genetic testing, and racial disparities in testing disappeared, emphasizing the value of providing additional education about the importance and purpose of genetic testing. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Breast cancer; Genetic counseling; Genetic testing; Genetics; Racial disparities |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240712 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| مُعرف محوري في PubMed: | PMC11236839 |
| DOI: | 10.1245/s10434-024-15434-2 |
| PMID: | 38811498 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1534-4681 |
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| DOI: | 10.1245/s10434-024-15434-2 |