دورية أكاديمية
G protein-specific mechanisms in the serotonin 5-HT 2A receptor regulate psychosis-related effects and memory deficits.
| العنوان: | G protein-specific mechanisms in the serotonin 5-HT |
|---|---|
| المؤلفون: | Kossatz E; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain., Diez-Alarcia R; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.; Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Bizkaia, Spain., Gaitonde SA; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada., Ramon-Duaso C; Cell-type mechanisms in normal and pathological behaviour Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain.; InterAx Biotech AG, PARK InnovAARE, 5234, Villigen, Switzerland., Aranda-Garcia D; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain.; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain., Muneta-Arrate I; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain., Tepaz E; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada., Saen-Oon S; NBD NOSTRUM BIODISCOVERY, Av. de Josep Tarradellas, 8-10, 3-2, 08029, Barcelona, Spain., Soliva R; NBD NOSTRUM BIODISCOVERY, Av. de Josep Tarradellas, 8-10, 3-2, 08029, Barcelona, Spain., Shahraki A; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany., Moreira D; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain., Brea J; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany.; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain., Loza MI; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain., de la Torre R; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain., Kolb P; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany., Bouvier M; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada., Meana JJ; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.; Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Bizkaia, Spain., Robledo P; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain. probledo@imim.es., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain. jana.selent@upf.edu.; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain. jana.selent@upf.edu. |
| المصدر: | Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4307. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Memory Disorders*/metabolism , Psychotic Disorders*/metabolism , Psychotic Disorders*/drug therapy , Receptor, Serotonin, 5-HT2A*/metabolism , Serotonin*/metabolism, Animals ; Female ; Humans ; Male ; Mice ; Brain/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; HEK293 Cells ; Schizophrenia/metabolism ; Signal Transduction |
| مستخلص: | G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications. This is the case for the serotonin 2 A receptor (5-HT (© 2024. The Author(s).) |
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| المشرفين على المادة: | EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gq-G11) 0 (Receptor, Serotonin, 5-HT2A) 333DO1RDJY (Serotonin) 0 (HTR2A protein, human) |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240529 Latest Revision: 20240606 |
| رمز التحديث: | 20240606 |
| مُعرف محوري في PubMed: | PMC11137019 |
| DOI: | 10.1038/s41467-024-48196-2 |
| PMID: | 38811567 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-48196-2 |