دورية أكاديمية
A Descriptive Study on the Clinical Profile and Outcomes of Patients with COVID-19 and Tuberculosis Co-infection.
| العنوان: | A Descriptive Study on the Clinical Profile and Outcomes of Patients with COVID-19 and Tuberculosis Co-infection. |
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| المؤلفون: | Benedicto JP; Division of Pulmonary Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila., Cruz EJM; Division of Pulmonary Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila., Quinto ML; Division of Pulmonary Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila. |
| المصدر: | Acta medica Philippina [Acta Med Philipp] 2024 May 15; Vol. 58 (8), pp. 42-49. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: College Of Medicine And Institute Of Hygiene University Of The Philipines Country of Publication: Philippines NLM ID: 0312677 Publication Model: eCollection Cited Medium: Internet ISSN: 2094-9278 (Electronic) Linking ISSN: 00016071 NLM ISO Abbreviation: Acta Med Philipp Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Manila : College Of Medicine And Institute Of Hygiene University Of The Philipines |
| مستخلص: | Background: Tuberculosis (TB) control has been a challenge in the country and its overall health impact remains significant. COVID-19 has caused significant morbidity and mortality especially among hospitalized patients. TB and COVID-19 co-infection (COVID-TB) may cause more catastrophic consequences and outcomes among afflicted individuals and management may be daunting. There is limited local data on COVID-TB. Objectives: The clinical profile of COVID-TB patients who were admitted were described. Comparison of the clinical outcomes was also done versus the general admitted COVID-19 patients without concomitant TB in the same institution. Relevant patient outcomes were reported which included admission to an intensive care unit (ICU), length of hospital stay, and mortality rate. Methods: This is a descriptive study on the demographics and clinical outcomes of patients admitted in the Philippine General Hospital (PGH) for COVID-19 with TB co-infection from March 2020 to September 2020. We aimed to characterize patients with COVID-TB and analyzed their outcomes. Results: There was a total of 79 patients who were admitted for COVID-19 (confirmed with RT-PCR) with TB co-infection during the study period. Majority of them were males (70.9%) with a median age of 54 (IQR 42 to 64) years. In terms of TB affliction, 75 (94.9%) patients were identified to have pulmonary tuberculosis. Majority of patients had at least one co-morbid illness with hypertension (16.5%), diabetes mellitus (13.9%), and heart failure (11.4%) as the most common. Respiratory symptoms (dyspnea and cough) were the predominant presenting complaint during hospital admission. Majority of the patients were classified as severe (8 or 10.1%) and critical (36 or 45.57%) COVID-19 disease. Fifty-six (70.9%) were bacteriologically confirmed tuberculosis. Radiologic imaging studies revealed findings consistent with pulmonary tuberculosis in 70 (88.61%) through plain radiograph. Forty-seven underwent HRCT and 46 of these (97.8%) had findings suggestive of PTB. Overall, 61 patients (77%) subsequently required oxygen supplementation. The in-hospital mortality within the study population was 36.7% (29/79) in contrast to the general COVID patients admitted in the same period which revealed significantly less fatality at 17.5% (35/200). The length of hospital stay was found to be 21.1 days ± 14.75 days across all study patients, and with median of 20 days for surviving patients. TB treatment outcomes were tracked in the 50 surviving COVID-19 patients where cure was declared in 8/50 (16%) while 22/50 (44%) successfully completed their six-month treatment regimen. Conclusions: This study of COVID-TB provides an initial evaluation of the potential association between active TB infection and COVID-19 severity and mortality. The data generated from this study may be a starting point to assess the interaction of these two diseases. Furthermore, bidirectional screening may be recommended even at hospitals' triage areas since both diseases may have similar presentations. Competing Interests: All authors declared no conflicts of interest. (© 2024 Acta Medica Philippina.) |
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| فهرسة مساهمة: | Keywords: COVID-19; co-infection; tuberculosis |
| تواريخ الأحداث: | Date Created: 20240530 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| مُعرف محوري في PubMed: | PMC11132287 |
| DOI: | 10.47895/amp.vi0.7855 |
| PMID: | 38812770 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2094-9278 |
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| DOI: | 10.47895/amp.vi0.7855 |