دورية أكاديمية
Dopamine infusion at typical infusion rates does not cause interference on plasma creatinine assays.
| العنوان: | Dopamine infusion at typical infusion rates does not cause interference on plasma creatinine assays. |
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| المؤلفون: | Cheng JYK; Department of Chemical Pathology, Prince of Wales Hospital, Hospital Authority, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong., Ranganatha Subramaniam S; Department of Chemical Pathology, Prince of Wales Hospital, Hospital Authority, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong., Yu SCY; Department of Chemical Pathology, Prince of Wales Hospital, Hospital Authority, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong., Lois Choy LY; Department of Chemical Pathology, Prince of Wales Hospital, Hospital Authority, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong., Kwok JSS; Department of Chemical Pathology, Prince of Wales Hospital, Hospital Authority, Hong Kong.; Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong. |
| المصدر: | Practical laboratory medicine [Pract Lab Med] 2024 May 15; Vol. 40, pp. e00399. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690848 Publication Model: eCollection Cited Medium: Print ISSN: 2352-5517 (Print) Linking ISSN: 23525517 NLM ISO Abbreviation: Pract Lab Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2015]- |
| مستخلص: | A Objectives: Dopamine is known to cause negative interference on enzymatic creatinine measurement. However, its effect on the Jaffe reaction, and its concentration required to interfere with enzymatic reactions, remain uncertain. This study was designed to study the interference of stable dopamine infusion on Jaffe and enzymatic creatinine assays, as well as the effect of dopamine infusion drip arm contamination on both creatinine assays. B Design and Methods: For the first part of the study, dopamine was spiked into pooled plasma samples at different concentrations to mimic the scenario of patients on dopamine infusion at an infusion rate between 2 and 20 μg/kg/min. For the second part, dopamine preparation of 2 g/L (same as the preparation used clinically) was mixed with pooled plasma samples at different proportions to mimic drip arm contamination. Creatinine concentrations were measured using Jaffe and enzymatic reactions. C Results: The first part showed that creatinine measurements were not interfered by dopamine infusion at an infusion rate between 2 and 20 μg/kg/min. The second part showed that dopamine could negatively interfere with enzymatic creatinine assays, even with minute drip arm contamination. The effect on the Jaffe reaction was less significant. D Discussion: Creatinine concentration could be reliably measured by Jaffe or enzymatic reactions if samples are from venous access sites other than the site of dopamine infusion. When dopamine interference on enzymatic creatinine assays is suspected, using the Jaffe reaction to cross-check may provide additional useful information. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.) |
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| فهرسة مساهمة: | Keywords: Creatinine; Dopamine; Interference |
| تواريخ الأحداث: | Date Created: 20240530 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| مُعرف محوري في PubMed: | PMC11133969 |
| DOI: | 10.1016/j.plabm.2024.e00399 |
| PMID: | 38812907 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2352-5517 |
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| DOI: | 10.1016/j.plabm.2024.e00399 |