دورية أكاديمية
Recent additions and access to a multidimensional lipidomic database containing liquid chromatography, ion mobility spectrometry, and tandem mass spectrometry information.
| العنوان: | Recent additions and access to a multidimensional lipidomic database containing liquid chromatography, ion mobility spectrometry, and tandem mass spectrometry information. |
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| المؤلفون: | Solosky AM; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kirkwood-Donelson KI; Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA., Odenkirk MT; Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO, USA., Baker ES; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. erinmsb@unc.edu. |
| المصدر: | Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 May 30. Date of Electronic Publication: 2024 May 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg : Springer-Verlag, 2002- |
| مستخلص: | The importance of lipids in biology continues to grow with their recent linkages to more diseases and conditions, microbiome fluctuations, and environmental exposures. These associations have motivated researchers to evaluate lipidomic changes in numerous matrices and studies. Lipidomic analyses, however, present numerous challenges as lipid species have broad chemistries that require different extraction methods and instrumental analyses to evaluate and separate their many isomers and isobars. Increasing knowledge about different lipid characteristics is therefore crucial for improving their separation and identification. Here, we present a multidimensional database for lipids analyzed on a platform combining reversed-phase liquid chromatography, drift tube ion mobility spectrometry, collision-induced dissociation, and mass spectrometry (RPLC-DTIMS-CID-MS). This platform and the different separation characteristics it provides enables more confident lipid annotations when compared to traditional tandem mass spectrometry platforms, especially when analyzing highly isomeric molecules such as lipids. This database expands on our previous publication containing only human plasma and bronchoalveolar lavage fluid lipids and provides experimental RPLC retention times, IMS collision cross section (CCS) values, and m/z information for 877 unique lipids from additional biofluids and tissues. Specifically, the database contains 1504 precursor [M + H] + , [M + NH (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.) |
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| معلومات مُعتمدة: | P42 ES027704 United States ES NIEHS NIH HHS; R01 GM141277 United States GM NIGMS NIH HHS; STAR RD 84003201 United States EPA EPA; ZIC ES103363 United States ImNIH Intramural NIH HHS |
| فهرسة مساهمة: | Keywords: Collision cross section; Database; Ion mobility spectrometry; Lipidomics; Lipids; Mass spectrometry; Reverse phase liquid chromatography (RPLC) |
| تواريخ الأحداث: | Date Created: 20240530 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00216-024-05351-4 |
| PMID: | 38814344 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1618-2650 |
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| DOI: | 10.1007/s00216-024-05351-4 |