دورية أكاديمية
IL-27 maintains cytotoxic Ly6C + γδ T cells that arise from immature precursors.
| العنوان: | IL-27 maintains cytotoxic Ly6C + γδ T cells that arise from immature precursors. |
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| المؤلفون: | Wiesheu R; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., Edwards SC; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., Hedley A; Cancer Research UK Scotland Institute, Glasgow, UK., Hall H; Cancer Research UK Scotland Institute, Glasgow, UK., Tosolini M; Cancer Research Centre of Toulouse, University of Toulouse, Toulouse, France., Fares da Silva MGF; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Sumaria N; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Castenmiller SM; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department Of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Wardak L; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department Of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Optaczy Y; Cancer Research UK Scotland Institute, Glasgow, UK., Lynn A; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., Hill DG; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Hayes AJ; School of Infection & Immunity, University of Glasgow, Glasgow, UK., Hay J; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Kilbey A; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., Shaw R; Cancer Research UK Scotland Institute, Glasgow, UK., Whyte D; Cancer Research UK Scotland Institute, Glasgow, UK., Walsh PJ; Cancer Research UK Scotland Institute, Glasgow, UK., Michie AM; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Graham GJ; School of Infection & Immunity, University of Glasgow, Glasgow, UK., Manoharan A; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Halsey C; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Blyth K; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., Wolkers MC; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department Of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Miller C; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Institute, Glasgow, UK., Pennington DJ; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Jones GW; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Fournie JJ; Cancer Research Centre of Toulouse, University of Toulouse, Toulouse, France., Bekiaris V; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Coffelt SB; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Seth.Coffelt@glasgow.ac.uk.; Cancer Research UK Scotland Institute, Glasgow, UK. Seth.Coffelt@glasgow.ac.uk. |
| المصدر: | The EMBO journal [EMBO J] 2024 Jul; Vol. 43 (14), pp. 2878-2907. Date of Electronic Publication: 2024 May 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : [London] : Nature Publishing Group Original Publication: Eynsham, Oxford, England : Published for the European Molecular Biology Organization by IRL Press, [c1982- |
| مواضيع طبية MeSH: | Antigens, Ly*/metabolism , Antigens, Ly*/genetics , Tumor Necrosis Factor Receptor Superfamily, Member 7*/metabolism , Tumor Necrosis Factor Receptor Superfamily, Member 7*/genetics , Tumor Necrosis Factor Receptor Superfamily, Member 7*/immunology , Receptors, Antigen, T-Cell, gamma-delta*/metabolism , Receptors, Antigen, T-Cell, gamma-delta*/immunology , Receptors, Antigen, T-Cell, gamma-delta*/genetics, Animals ; Mice ; Humans ; Interferon-gamma/metabolism ; Interferon-gamma/immunology ; Interleukin-27/metabolism ; Interleukin-27/genetics ; Cell Differentiation/immunology ; Mice, Inbred C57BL ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism |
| مستخلص: | In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Unlike αβ-T cells that rely on MHC-presented peptides to drive their terminal differentiation, it is unclear whether MHC-unrestricted γδ-T cells undergo further functional maturation after exiting the thymus. Here, we provide evidence of phenotypic and functional diversity within peripheral IFNγ-producing γδ T cells. We found that CD27 + Ly6C - cells convert into CD27 + Ly6C + cells, and these CD27 + Ly6C + cells control cancer progression in mice, while the CD27 + Ly6C - cells cannot. The gene signatures of these two subsets were highly analogous to human immature and mature γδ-T cells, indicative of conservation across species. We show that IL-27 supports the cytotoxic phenotype and function of mouse CD27 + Ly6C + cells and human Vδ2 + cells, while IL-27 is dispensable for mouse CD27 + Ly6C - cell and human Vδ1 + cell functions. These data reveal increased complexity within IFNγ-producing γδ-T cells, comprising immature and terminally differentiated subsets, that offer new insights into unconventional T-cell biology. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 2019DecPhD1349 Breast Cancer Now (BCN); BB/R017808/1 UKRI | Biotechnology and Biological Sciences Research Council (BBSRC); MR/V010972/1 UKRI | Medical Research Council (MRC); 217093/Z/19/Z Wellcome Trust (WT); n/a Annie McNab Bequest; 2020 24 Little Princess Trust (LPT); 22706 United Kingdom VAC_ Versus Arthritis; S17-17 Tenovus (Tenovus Cancer Care); n/a Stichting Sanquin Bloedvoorziening (Sanquin Blood Supply Foundation); C596/A25142,A31287,A29799,A29801,DRCPFA-Nov21\100001 Cancer Research UK (CRUK); 208990/Z/17/Z Wellcome Trust (WT); United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: Cancer; Differentiation; IL-27; Innate; γδ T Cells |
| المشرفين على المادة: | 0 (Antigens, Ly) 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7) 0 (Receptors, Antigen, T-Cell, gamma-delta) 0 (Ly-6C antigen, mouse) 82115-62-6 (Interferon-gamma) 0 (Interleukin-27) |
| تواريخ الأحداث: | Date Created: 20240530 Date Completed: 20240715 Latest Revision: 20240813 |
| رمز التحديث: | 20240813 |
| مُعرف محوري في PubMed: | PMC11251046 |
| DOI: | 10.1038/s44318-024-00133-1 |
| PMID: | 38816652 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-2075 |
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| DOI: | 10.1038/s44318-024-00133-1 |