دورية أكاديمية
أعرض في EDS

Extensive scintigraphic gastric motor function testing with concurrent symptom recording predicts prospectively measured daily dyspeptic symptoms.

التفاصيل البيبلوغرافية
العنوان: Extensive scintigraphic gastric motor function testing with concurrent symptom recording predicts prospectively measured daily dyspeptic symptoms.
المؤلفون: Wang XJ; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., O'Connor M; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Peck T; Division of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Johnston G; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Prichard DO; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Gastroenterology and Hepatology, St James' Hospital, Dublin, Ireland.; University of Dublin, Trinity College, Dublin, Ireland.
المصدر: Neurogastroenterology and motility [Neurogastroenterol Motil] 2024 Aug; Vol. 36 (8), pp. e14819. Date of Electronic Publication: 2024 May 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9432572 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2982 (Electronic) Linking ISSN: 13501925 NLM ISO Abbreviation: Neurogastroenterol Motil Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Osney Mead, Oxford, UK : Blackwell Scientific Publications, c1994-
مواضيع طبية MeSH: Dyspepsia*/diagnostic imaging , Dyspepsia*/physiopathology , Gastric Emptying*/physiology , Radionuclide Imaging*/methods, Humans ; Female ; Male ; Adult ; Middle Aged ; Prospective Studies ; Gastrointestinal Motility/physiology ; Gastroparesis/diagnostic imaging ; Gastroparesis/physiopathology ; Gastroparesis/diagnosis ; Young Adult
مستخلص: Background: Absent "organic" disease, dyspeptic symptoms may arise from abnormal gastric sensation, accommodation, motility or emptying (GE). Extensive gastric sensorimotor evaluation is rarely undertaken because testing is prolonged, invasive, poorly tolerated or unavailable.
Aims: To investigate whether gastric antral motor function, evaluated with scintigraphy, predicts GE. To explore whether motor testing with symptom recording predicts day-to-day symptoms in patients with dyspepsia.
Methods: GE was determined using a scintigraphic solid-meal protocol (296 kcal, 35% fat). Antral motility was estimated from 10 min of scintigraphic time-activity curves acquired 40 min after meal consumption. An antral motility index (MI) was derived from contraction amplitude and frequency. Intra-gastric distribution of the meal on scintograms at 1 h (IGD1) was determined. Meal-induced symptoms were evaluated by questionnaire. Patients completed the Gastroparesis Cardinal Symptom Index Daily Diary (GCSI-DD) for 14 days.
Results: Twelve healthy participants and 23 prospectively recruited patients completed the study. Nine patients had delayed, and 2 had rapid, GE. In univariate analysis MI explained 42% of GE half-time. In multivariate analysis MI and GE half-time explained 25% of the variance in meal-induced symptoms. While scintigraphic evaluation of gastric motor function with symptom recording explained 80% of the variance in the GCSI-DD, meal-induced symptoms were the only significant predictor. However, among patients with delayed GE, MI, GE half-time, IGD1, and meal-induced symptoms all significantly predicted GCSI-DD.
Conclusions: Antral motility predicts GE. In exploratory analyses, only meal-induced symptoms predicted daily symptoms among patients with dyspepsia. However, motor function also predicted symptoms in patients with delayed GE.
(© 2024 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: U24 DK076169 United States DK NIDDK NIH HHS; U24 DK115255 United States DK NIDDK NIH HHS; UL1 TR002377 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: antral contractility; functional dyspepsia; gastric emptying; gastrointestinal symptoms; gastroparesis; human
تواريخ الأحداث: Date Created: 20240531 Date Completed: 20240712 Latest Revision: 20240827
رمز التحديث: 20240827
مُعرف محوري في PubMed: PMC11344222
DOI: 10.1111/nmo.14819
PMID: 38816956
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2982
DOI:10.1111/nmo.14819