دورية أكاديمية
أعرض في EDS

The Impact of Coronary Artery Disease on Outcomes in Patients Hospitalized With Pre-eclampsia.

التفاصيل البيبلوغرافية
العنوان: The Impact of Coronary Artery Disease on Outcomes in Patients Hospitalized With Pre-eclampsia.
المؤلفون: Elkattawy O; Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA., Shah Y; Radiology, Rutgers University New Jersey Medical School, Newark, USA., Alimdjanova S; Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA., Ghbrial M; Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA., Javed J; Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA., Mohamed O; Medicine, Saint Barnabas Medical Center, Livingston, USA., Dayal M; Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA., Hossain A; Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA., Elkattawy S; Cardiology, Saint Joseph University Medical Center, Paterson, USA., Shamoon F; Cardiology, Saint Joseph University Medical Center, Paterson, USA.
المصدر: Cureus [Cureus] 2024 Apr 29; Vol. 16 (4), pp. e59309. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Introduction Pre-eclampsia leads to long-lasting cardiovascular effects in women in the postpartum period, but prevalence and in-hospital adverse events of coronary artery disease (CAD) in women with pre-eclampsia are poorly understood. The prevalence, outcomes, and mortality risks identified in this study allow for possible routes of clinical intervention of CAD in women with pre-eclampsia. The purpose of this study was to determine the prevalence and outcomes of CAD in women diagnosed with pre-eclampsia compared to those with pre-eclampsia with no history of CAD. Predictors of mortality in pre-eclampsia were also analyzed. Methods Data were obtained from the National Inpatient Sample from January 2016 to December 2019. We used the multivariate logistic regression to assess the independent association of CAD with outcomes in patients admitted with pre-eclampsia. We also used the multivariate logistic regression to analyze predictors of mortality in patients hospitalized with pre-eclampsia. Results Women with pre-eclampsia admitted between January 2016 and December 2019 were included in our analysis. A total of 256,010 patients were diagnosed with pre-eclampsia. Of these patients, 174 (0.1%) patients had CAD. Multivariate analysis demonstrated that CAD in patients with pre-eclampsia was independently associated with angioplasty (adjusted odds ratio [aOR] 62.28; 95% CI 20.459-189.591; p=0.001), permanent pacemaker (aOR 35.129; 95% CI 13.821-89.287; p=0.001), left heart catheterization (aOR 29.416; 95% CI 7.236-119.557; p=0.001), non-ST-elevation myocardial infarction (NSTEMI) (aOR 25.832; 95% CI 7.653-87.189; p=0.001), and congestive heart failure (CHF) (aOR 13.948; 95% CI 7.648-25.438; p=0.001). We also used the multivariate logistic regression model to assess predictors of mortality in patients admitted with pre-eclampsia. These included age at admission (aOR 1.064; 95% CI 1.009-1.121; p=0.021), Asian/Pacific-Islander race (aOR 4.893; 95% CI 1.884-12.711; p=0.001), and comorbidities such as CHF (aOR 19.405; 95% CI 6.408-58.768; p=0.001), eclampsia (aOR 17.253; 95% CI 5.323-55.924; p=0.001), syndrome of HELLP (hemolysis, elevated liver enzymes, low platelets) (aOR 6.204; 95% CI 2.849-13.510; p=0.001), coagulopathy (aOR 6.524; 95% CI 1.997-21.308; p=0.002), and liver disease (aOR 5.217; 95% CI 1.156-23.554; p=0.032). Conclusion In a large cohort of patients admitted with pre-eclampsia, we found the prevalence of CAD to be 0.1%. CAD was associated with several clinical outcomes, including NSTEMI. Predictors of mortality in patients with pre-eclampsia included demographic variables such as age and Asian race, as well as comorbidities such as CHF and coagulopathy.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Elkattawy et al.)
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فهرسة مساهمة: Keywords: cardio-obstetrics; cardiology; coronary artery disease; pre-eclampsia; preventive cardiology
تواريخ الأحداث: Date Created: 20240531 Latest Revision: 20240601
رمز التحديث: 20240601
مُعرف محوري في PubMed: PMC11136588
DOI: 10.7759/cureus.59309
PMID: 38817475
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.59309