دورية أكاديمية
Tricuspid valve and right-heart chamber remodelling in elderly subjects with secondary tricuspid regurgitation.
| العنوان: | Tricuspid valve and right-heart chamber remodelling in elderly subjects with secondary tricuspid regurgitation. |
|---|---|
| المؤلفون: | Abdelghani M; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.; Cardiology Unit, Department of Internal Medicine, Sohar Hospital, Sohar, Oman.; Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Mohey S; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Elnahas AM; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Elshernouby KA; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Muharram M; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Gebaly M; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Mokhaimar B; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Elbadawi M; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Diab RA; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Abdelshafy M; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.; Department of Cardiology, University of Galway, Galway, Ireland., Soliman O; Department of Cardiology, University of Galway, Galway, Ireland.; CORRIB Core Lab, University of Galway, Galway, Ireland., Attia W; Faculty of Medicine, Al-Azhar University, Cairo, Egypt. |
| المصدر: | Acta cardiologica [Acta Cardiol] 2024 May 31, pp. 1-10. Date of Electronic Publication: 2024 May 31. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1784-973X (Electronic) Linking ISSN: 00015385 NLM ISO Abbreviation: Acta Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : London : Taylor & Francis Original Publication: Bruxelles : Acta Medica Belgica |
| مستخلص: | Background: The prevalence of secondary tricuspid regurgitation (TR) increases with ageing, but the exact mechanisms and the pattern of tricuspid valve (TV) remodelling are yet to be defined. This knowledge is needed to guide patient selection for the evolving therapeutic options. We sought to explore the prevalence and predictors of secondary TR in the elderly, as well as the associated pattern of right-heart chamber and TV remodelling. Methods: Consecutive older subjects (60-year-old or older) were prospectively enrolled and detailed analysis of right-heart chambers and TV was conducted (ClinicalTrials.gov ID: NCT05784883). TR severity was defined based on a multiparametric approach. Results: Out of 213 patients (age, 67.1 ± 5.9 years, 52.6% female), 48.8% had mild and 15.5% had moderate-severe TR. The frequency of moderate-severe TR increased from 4.5% in those without to 32.9% in those with underlying abnormalities of the left/right heart. There was a significant trend of worsening right-heart chamber and TV remodelling across the three grades of TR severity (none-trace, mild, and moderate-severe; p-value for linear trend < 0.001). ROC curve-defined cut-points of TV remodelling parameters predicting moderate-severe TR were annular dilatation ≥3.75 cm (AUC: 0.74), tenting area ≥1.45 cm 2 (AUC: 0.67), and leaflet length ≥2.25 cm (AUC: 0.61) with increasing frequency of moderate-severe TR from 7.2% through 64.7%, in those with none vs. all three criteria ( p < 0.001). The most important correlate of the three TV remodelling parameters was right ventricular and atrial (RV and RA) dilatation. Conclusion: Rather than ageing per se, the presence of underlying cardiac abnormalities determines the frequency of moderate-severe TR. Progressive remodelling of right-heart chambers and TV geometry starts with the development of mild TR. TA dilatation, increased tenting, and leaflet elongation are three important correlates of the development of TR that parallel progressive RV and RA dilatation. Study Registration: ClinicalTrials.gov ID: NCT05784883. |
| فهرسة مساهمة: | Keywords: Tricuspid valve; atrial; regurgitation; remodelling; right ventricle |
| سلسلة جزيئية: | ClinicalTrials.gov NCT05784883 |
| تواريخ الأحداث: | Date Created: 20240531 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1080/00015385.2024.2359657 |
| PMID: | 38818766 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1784-973X |
|---|---|
| DOI: | 10.1080/00015385.2024.2359657 |