دورية أكاديمية
Th17-to-Tfh plasticity during periodontitis limits disease pathology.
العنوان: | Th17-to-Tfh plasticity during periodontitis limits disease pathology. |
---|---|
المؤلفون: | McClure FA; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Wemyss K; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Cox JR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Bridgeman HM; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Prise IE; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., King JI; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Jaigirdar S; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Whelan A; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Jones GW; Cellular and Molecular Medicine, University of Bristol , Bristol, UK., Grainger JR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Hepworth MR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Konkel JE; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK. |
المصدر: | The Journal of experimental medicine [J Exp Med] 2024 Aug 05; Vol. 221 (8). Date of Electronic Publication: 2024 May 31. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
مواضيع طبية MeSH: | Th17 Cells*/immunology , Periodontitis*/immunology , Periodontitis*/pathology , Cell Plasticity*/immunology , Interleukin-17*/metabolism , Interleukin-17*/immunology, Animals ; Mice ; Interleukin-6/metabolism ; Mice, Inbred C57BL ; T Follicular Helper Cells/immunology ; Gingiva/immunology ; Gingiva/pathology ; Immunoglobulin G/immunology ; Alveolar Bone Loss/immunology ; Alveolar Bone Loss/pathology |
مستخلص: | Th17 cell plasticity is crucial for development of autoinflammatory disease pathology. Periodontitis is a prevalent inflammatory disease where Th17 cells mediate key pathological roles, yet whether they exhibit any functional plasticity remains unexplored. We found that during periodontitis, gingival IL-17 fate-mapped T cells still predominantly produce IL-17A, with little diversification of cytokine production. However, plasticity of IL-17 fate-mapped cells did occur during periodontitis, but in the gingiva draining lymph node. Here, some Th17 cells acquired features of Tfh cells, a functional plasticity that was dependent on IL-6. Notably, Th17-to-Tfh diversification was important to limit periodontitis pathology. Preventing Th17-to-Tfh plasticity resulted in elevated periodontal bone loss that was not simply due to increased proportions of conventional Th17 cells. Instead, loss of Th17-to-Tfh cells resulted in reduced IgG levels within the oral cavity and a failure to restrict the biomass of the oral commensal community. Thus, our data identify a novel protective function for a subset of otherwise pathogenic Th17 cells during periodontitis. (© 2024 McClure et al.) |
References: | J Periodontal Res. 2015 Aug;50(4):535-43. (PMID: 25330403) J Immunol. 2015 Aug 15;195(4):1427-35. (PMID: 26150532) J Periodontol. 1978 Dec;49(12):631-4. (PMID: 366101) Immunity. 2009 Jan 16;30(1):92-107. (PMID: 19119024) Gastroenterol Clin North Am. 1991 Sep;20(3):397-439. (PMID: 1917020) Mucosal Immunol. 2016 Sep;9(5):1163-1172. (PMID: 26732676) Br Dent J. 2012 Dec;213(11):567-72. (PMID: 23222333) J Clin Periodontol. 2015 Sep;42(9):817-823. (PMID: 26205081) Nat Immunol. 2011 Mar;12(3):255-63. (PMID: 21278737) J Periodontal Res. 2021 Oct;56(5):863-876. (PMID: 33826149) Mol Oral Microbiol. 2015 Apr;30(2):160-9. (PMID: 25219939) Eur J Immunol. 2010 Dec;40(12):3336-46. (PMID: 21110317) Science. 2009 Aug 21;325(5943):1001-5. (PMID: 19628815) Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047) Nat Immunol. 2020 Mar;21(3):321-330. (PMID: 32066949) Cell Rep. 2023 Jan 31;42(1):111981. (PMID: 36640306) Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):. (PMID: 34479995) Clin Vaccine Immunol. 2009 Dec;16(12):1766-73. (PMID: 19793900) Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10738-10743. (PMID: 30279177) Immunity. 2011 Dec 23;35(6):972-85. (PMID: 22177921) Methods Mol Biol. 2018;1725:101-118. (PMID: 29322412) Immunity. 2011 Dec 23;35(6):986-96. (PMID: 22177922) Blood. 2002 Jul 15;100(2):560-8. (PMID: 12091349) Cell. 2021 Dec 22;184(26):6281-6298.e23. (PMID: 34875227) Sci Transl Med. 2014 Mar 26;6(229):229ra40. (PMID: 24670684) Cell. 2015 Dec 3;163(6):1400-12. (PMID: 26607794) Immunity. 2017 Jan 17;46(1):133-147. (PMID: 28087239) Nat Immunol. 2011 Jun;12(6):568-75. (PMID: 21516111) Nat Commun. 2018 Feb 16;9(1):701. (PMID: 29453398) Immunity. 2019 Jul 16;51(1):77-89.e6. (PMID: 31229354) Elife. 2021 Jan 04;10:. (PMID: 33393902) Oral Microbiol Immunol. 2009 Feb;24(1):1-6. (PMID: 19121062) Front Immunol. 2019 Jun 25;10:1403. (PMID: 31293577) J Immunol. 2013 Oct 1;191(7):3705-11. (PMID: 23980208) Periodontol 2000. 2022 Jun;89(1):9-18. (PMID: 35244969) Cell Host Microbe. 2011 Nov 17;10(5):497-506. (PMID: 22036469) J Immunol. 2013 Apr 1;190(7):3049-53. (PMID: 23447690) Lancet Reg Health Eur. 2021 Nov 22;13:100266. (PMID: 34950923) Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7061-6. (PMID: 26038559) Sci Transl Med. 2018 Oct 17;10(463):. (PMID: 30333238) Microbiome. 2018 May 17;6(1):90. (PMID: 29773078) J Clin Invest. 2009 Mar;119(3):565-72. (PMID: 19188681) Cell. 2021 Jul 22;184(15):4090-4104.e15. (PMID: 34129837) Immunity. 2014 Mar 20;40(3):355-66. (PMID: 24530058) Nat Immunol. 2013 Apr;14(4):372-9. (PMID: 23475182) Elife. 2015 Jan 08;4:e04851. (PMID: 25569154) Arthritis Res Ther. 2019 May 2;21(1):111. (PMID: 31046809) Bio Protoc. 2017 Dec 20;7(24):. (PMID: 29333479) Curr Opin Biotechnol. 2020 Oct;65:284-295. (PMID: 32889231) Nat Immunol. 2014 Sep;15(9):856-65. (PMID: 25064073) Acta Odontol Scand. 1987 Jun;45(3):187-93. (PMID: 3497517) Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288) Immunity. 2009 Sep 18;31(3):491-501. (PMID: 19733096) |
معلومات مُعتمدة: | 105644/Z/14/Z Royal Society; BB/M025977/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; 224467/Z/21/Z United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust; University of Manchester; Lister Institute for Preventative Medicine; Kennedy Trust for Rheumatology Research; United Kingdom VAC_ Versus Arthritis |
المشرفين على المادة: | 0 (Interleukin-17) 0 (Interleukin-6) 0 (Immunoglobulin G) |
تواريخ الأحداث: | Date Created: 20240531 Date Completed: 20240531 Latest Revision: 20240603 |
رمز التحديث: | 20240603 |
مُعرف محوري في PubMed: | PMC11143381 |
DOI: | 10.1084/jem.20232015 |
PMID: | 38819409 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1540-9538 |
---|---|
DOI: | 10.1084/jem.20232015 |