دورية أكاديمية
Th17-to-Tfh plasticity during periodontitis limits disease pathology.
| العنوان: | Th17-to-Tfh plasticity during periodontitis limits disease pathology. |
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| المؤلفون: | McClure FA; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Wemyss K; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Cox JR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Bridgeman HM; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Prise IE; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., King JI; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Jaigirdar S; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Whelan A; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Jones GW; Cellular and Molecular Medicine, University of Bristol , Bristol, UK., Grainger JR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Hepworth MR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK., Konkel JE; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2024 Aug 05; Vol. 221 (8). Date of Electronic Publication: 2024 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Th17 Cells*/immunology , Periodontitis*/immunology , Periodontitis*/pathology , Cell Plasticity*/immunology , Interleukin-17*/metabolism , Interleukin-17*/immunology, Animals ; Mice ; Interleukin-6/metabolism ; Mice, Inbred C57BL ; T Follicular Helper Cells/immunology ; Gingiva/immunology ; Gingiva/pathology ; Immunoglobulin G/immunology ; Alveolar Bone Loss/immunology ; Alveolar Bone Loss/pathology |
| مستخلص: | Th17 cell plasticity is crucial for development of autoinflammatory disease pathology. Periodontitis is a prevalent inflammatory disease where Th17 cells mediate key pathological roles, yet whether they exhibit any functional plasticity remains unexplored. We found that during periodontitis, gingival IL-17 fate-mapped T cells still predominantly produce IL-17A, with little diversification of cytokine production. However, plasticity of IL-17 fate-mapped cells did occur during periodontitis, but in the gingiva draining lymph node. Here, some Th17 cells acquired features of Tfh cells, a functional plasticity that was dependent on IL-6. Notably, Th17-to-Tfh diversification was important to limit periodontitis pathology. Preventing Th17-to-Tfh plasticity resulted in elevated periodontal bone loss that was not simply due to increased proportions of conventional Th17 cells. Instead, loss of Th17-to-Tfh cells resulted in reduced IgG levels within the oral cavity and a failure to restrict the biomass of the oral commensal community. Thus, our data identify a novel protective function for a subset of otherwise pathogenic Th17 cells during periodontitis. (© 2024 McClure et al.) |
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| معلومات مُعتمدة: | 105644/Z/14/Z Royal Society; BB/M025977/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; 224467/Z/21/Z United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust; University of Manchester; Lister Institute for Preventative Medicine; Kennedy Trust for Rheumatology Research; United Kingdom VAC_ Versus Arthritis |
| المشرفين على المادة: | 0 (Interleukin-17) 0 (Interleukin-6) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20240531 Date Completed: 20240531 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| مُعرف محوري في PubMed: | PMC11143381 |
| DOI: | 10.1084/jem.20232015 |
| PMID: | 38819409 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-9538 |
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| DOI: | 10.1084/jem.20232015 |