دورية أكاديمية
Investigation of the pathogen-specific antibody response in periprosthetic joint infection.
| العنوان: | Investigation of the pathogen-specific antibody response in periprosthetic joint infection. |
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| المؤلفون: | Janz V; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; Sporthopaedicum, 93053, Regensburg, Germany., Rakow A; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Schröder L; Institute of Immunology, University Medicine Greifswald, 17475, Greifswald, Germany., Hofer A; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Wiebe S; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Schoon J; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475, Greifswald, Germany., Bröker BM; Institute of Immunology, University Medicine Greifswald, 17475, Greifswald, Germany., Wassilew GI; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Raafat D; Institute of Immunology, University Medicine Greifswald, 17475, Greifswald, Germany. dina.raafat@med.uni-greifswald.de.; Department of Microbiology and Immunology, Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt. dina.raafat@med.uni-greifswald.de. |
| المصدر: | Infection [Infection] 2024 May 31. Date of Electronic Publication: 2024 May 31. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Heidelberg : Springer Heidelberg Original Publication: München, Verlagsgesellschaft Otto Spatz. |
| مستخلص: | Purpose: Periprosthetic joint infections (PJIs) are a very demanding complication of arthroplasty. Diagnosis of PJI and pathogen identification pose considerable challenges in clinical practice. We hypothesized that the pathogen-specific immune response to PJI reflects the infection process, provides clinically relevant information on disease course, and has the potential to further optimize antimicrobial therapy. Methods: We conducted a prospective matched cohort pilot study with 13 patients undergoing two-stage septic revision arthroplasty (PJI patients) between 06/2020 and 06/2021, as well as 11 control patients undergoing one-stage aseptic revision arthroplasty (Non-PJI patients). Pre-, intra- and postoperative serum samples were collected at standardized time points. We developed a custom Luminex®-based quantitative bead-based suspension array (Infection Array; IA), and used it for simultaneous measurement of antibody specificities against 32 pathogens commonly associated with PJI in 267 serum samples. Results: The IA was able to trace the dynamics of the pathogen-specific humoral immune response in all patients against PJI-related pathogens, prominently coagulase-negative staphylococci and streptococci. Pathogen-specific serum antibody titers declined in 62% of PJI patients over the course of treatment, while no changes in antibody titers were observed in 82% of Non-PJI patients during this study. Our serological data strongly suggested that antibody signatures reflect an immune response to microbial invasion. Conclusion: Our results provide insights into the pathophysiology of PJI and information on the individual disease courses. The IA is therefore a promising and novel serological tool of high resolution for monitoring the immunoproteomic footprints of infectious pathogens in the course of PJI. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | FOVB-2020-07 Research Network Molecular Medicine (FVMM) of the University Medicine Greifswald |
| فهرسة مساهمة: | Keywords: Disease monitoring; Infection Array; PJI; Pathogen-specific antibody response; Periprosthetic joint infection; Serology |
| تواريخ الأحداث: | Date Created: 20240531 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1007/s15010-024-02285-y |
| PMID: | 38819638 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1439-0973 |
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| DOI: | 10.1007/s15010-024-02285-y |